| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATE1 | SPCS2 | ENSP00000224652 | ENSP00000263672 | Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity). | Signal peptidase complex subunit 2; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. | 0.443 |
| ATE1 | XRRA1 | ENSP00000224652 | ENSP00000339918 | Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity). | X-ray radiation resistance-associated protein 1; May be involved in the response of cells to X-ray radiation. | 0.479 |
| BICRA | XRRA1 | ENSP00000379946 | ENSP00000339918 | BRD4-interacting chromatin-remodeling complex-associated protein; Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP- dependent manner. May play a role in BRD4-mediated gene transcription. | X-ray radiation resistance-associated protein 1; May be involved in the response of cells to X-ray radiation. | 0.473 |
| GASK1B | GLRB | ENSP00000377396 | ENSP00000264428 | Golgi associated kinase 1B; Belongs to the GASK family. | Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. | 0.480 |
| GASK1B | XRRA1 | ENSP00000377396 | ENSP00000339918 | Golgi associated kinase 1B; Belongs to the GASK family. | X-ray radiation resistance-associated protein 1; May be involved in the response of cells to X-ray radiation. | 0.473 |
| GLRB | GASK1B | ENSP00000264428 | ENSP00000377396 | Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. | Golgi associated kinase 1B; Belongs to the GASK family. | 0.480 |
| GLRB | XRRA1 | ENSP00000264428 | ENSP00000339918 | Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. | X-ray radiation resistance-associated protein 1; May be involved in the response of cells to X-ray radiation. | 0.460 |
| SLC9A8 | XRRA1 | ENSP00000416418 | ENSP00000339918 | Sodium/hydrogen exchanger 8; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | X-ray radiation resistance-associated protein 1; May be involved in the response of cells to X-ray radiation. | 0.461 |
| SPCS2 | ATE1 | ENSP00000263672 | ENSP00000224652 | Signal peptidase complex subunit 2; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. | Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity). | 0.443 |
| SPCS2 | TBC1D22A | ENSP00000263672 | ENSP00000336724 | Signal peptidase complex subunit 2; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s). | 0.434 |
| SPCS2 | XRRA1 | ENSP00000263672 | ENSP00000339918 | Signal peptidase complex subunit 2; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. | X-ray radiation resistance-associated protein 1; May be involved in the response of cells to X-ray radiation. | 0.627 |
| TAFA5 | XRRA1 | ENSP00000383933 | ENSP00000339918 | Chemokine-like protein TAFA-5; Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (By similarity). Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (By similarity). Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (By similarity). Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2 (By simila [...] | X-ray radiation resistance-associated protein 1; May be involved in the response of cells to X-ray radiation. | 0.485 |
| TBC1D22A | SPCS2 | ENSP00000336724 | ENSP00000263672 | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s). | Signal peptidase complex subunit 2; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. | 0.434 |
| TBC1D22A | XRRA1 | ENSP00000336724 | ENSP00000339918 | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s). | X-ray radiation resistance-associated protein 1; May be involved in the response of cells to X-ray radiation. | 0.490 |
| TMEM45B | XRRA1 | ENSP00000281441 | ENSP00000339918 | Transmembrane protein 45B. | X-ray radiation resistance-associated protein 1; May be involved in the response of cells to X-ray radiation. | 0.475 |
| XRCC5 | XRRA1 | ENSP00000375978 | ENSP00000339918 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic s [...] | X-ray radiation resistance-associated protein 1; May be involved in the response of cells to X-ray radiation. | 0.764 |
| XRRA1 | ATE1 | ENSP00000339918 | ENSP00000224652 | X-ray radiation resistance-associated protein 1; May be involved in the response of cells to X-ray radiation. | Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity). | 0.479 |
| XRRA1 | BICRA | ENSP00000339918 | ENSP00000379946 | X-ray radiation resistance-associated protein 1; May be involved in the response of cells to X-ray radiation. | BRD4-interacting chromatin-remodeling complex-associated protein; Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP- dependent manner. May play a role in BRD4-mediated gene transcription. | 0.473 |
| XRRA1 | GASK1B | ENSP00000339918 | ENSP00000377396 | X-ray radiation resistance-associated protein 1; May be involved in the response of cells to X-ray radiation. | Golgi associated kinase 1B; Belongs to the GASK family. | 0.473 |
| XRRA1 | GLRB | ENSP00000339918 | ENSP00000264428 | X-ray radiation resistance-associated protein 1; May be involved in the response of cells to X-ray radiation. | Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. | 0.460 |
