Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
YIPF3Protein YIPF3, 36 kDa form III; Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis. (350 aa)    
Predicted Functional Partners:
YIPF4
Protein YIPF4; Involved in the maintenance of the Golgi structure. Belongs to the YIP1 family.
   
 
 0.994
YIPF2
Protein YIPF2; Yip1 domain family member 2.
   
  
 0.831
YIPF1
Protein YIPF1; Yip1 domain family member 1; Belongs to the YIP1 family.
   
  
 0.745
YIPF5
Protein YIPF5; Plays a role in transport between endoplasmic reticulum and Golgi.
   
 
 0.736
SCEL
Sciellin; May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.
      
 0.717
UNC93B1
Protein unc-93 homolog B1; Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal. Belongs to the unc-93 family.
    
   0.707
YIPF6
Protein YIPF6; May be required for stable YIPF1 and YIPF2 protein expression.
   
  
 0.701
LETMD1
LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53.
   
   0.679
YIF1A
Protein YIF1A; Possible role in transport between endoplasmic reticulum and Golgi; Belongs to the YIF1 family.
   
  
 0.674
SYNPO
Synaptopodin; Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity).
    
 
 0.671
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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