Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ZBBXZinc finger B-box domain containing. (839 aa)    
Predicted Functional Partners:
WDR49
WD repeat domain 49.
   
  
 0.699
WDR60
WD repeat-containing protein 60; May play a role in ciliogenesis.
   
   0.672
TTC29
Tetratricopeptide repeat domain 29.
   
  
 0.669
CFAP52
Cilia- and flagella-associated protein 52; May play a role in cell growth and/or survival. Belongs to the CFAP52 family.
   
  
 0.581
LRRIQ1
Leucine rich repeats and IQ motif containing 1.
   
  
 0.525
CFAP43
Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.
   
    0.485
RGS9BP
Regulator of G-protein signaling 9-binding protein; Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protectin [...]
      
 0.480
ASXL3
Putative Polycomb group protein ASXL3; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity); Belongs to the Asx family.
   
  
 0.479
TEKT1
Tektin-1; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules; Belongs to the tektin family.
   
  
 0.466
DHX32
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32; DEAH-box helicase 32; Belongs to the DEAD box helicase family. DEAH subfamily.
    
   0.462
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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