| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DAP3 | MRPS2 | ENSP00000357320 | ENSP00000360850 | 28S ribosomal protein S29, mitochondrial; Involved in mediating interferon-gamma-induced cell death; Belongs to the mitochondrion-specific ribosomal protein mS29 family. | 28S ribosomal protein S2, mitochondrial; Required for mitoribosome formation and stability, and mitochondrial translation; Belongs to the universal ribosomal protein uS2 family. | 0.999 |
| DAP3 | MRPS7 | ENSP00000357320 | ENSP00000245539 | 28S ribosomal protein S29, mitochondrial; Involved in mediating interferon-gamma-induced cell death; Belongs to the mitochondrion-specific ribosomal protein mS29 family. | Mitochondrial ribosomal protein S7. | 0.999 |
| DAP3 | TRIM28 | ENSP00000357320 | ENSP00000253024 | 28S ribosomal protein S29, mitochondrial; Involved in mediating interferon-gamma-induced cell death; Belongs to the mitochondrion-specific ribosomal protein mS29 family. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.477 |
| DAP3 | ZNF133 | ENSP00000357320 | ENSP00000439427 | 28S ribosomal protein S29, mitochondrial; Involved in mediating interferon-gamma-induced cell death; Belongs to the mitochondrion-specific ribosomal protein mS29 family. | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor. | 0.700 |
| DZANK1 | RBBP9 | ENSP00000262547 | ENSP00000336866 | Double zinc ribbon and ankyrin repeat domains 1. | Serine hydrolase RBBP9; Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1. | 0.612 |
| DZANK1 | ZNF133 | ENSP00000262547 | ENSP00000439427 | Double zinc ribbon and ankyrin repeat domains 1. | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor. | 0.604 |
| LGALS4 | ZNF133 | ENSP00000302100 | ENSP00000439427 | Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions. | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor. | 0.566 |
| MRPS2 | DAP3 | ENSP00000360850 | ENSP00000357320 | 28S ribosomal protein S2, mitochondrial; Required for mitoribosome formation and stability, and mitochondrial translation; Belongs to the universal ribosomal protein uS2 family. | 28S ribosomal protein S29, mitochondrial; Involved in mediating interferon-gamma-induced cell death; Belongs to the mitochondrion-specific ribosomal protein mS29 family. | 0.999 |
| MRPS2 | MRPS7 | ENSP00000360850 | ENSP00000245539 | 28S ribosomal protein S2, mitochondrial; Required for mitoribosome formation and stability, and mitochondrial translation; Belongs to the universal ribosomal protein uS2 family. | Mitochondrial ribosomal protein S7. | 0.999 |
| MRPS2 | TPD52 | ENSP00000360850 | ENSP00000429309 | 28S ribosomal protein S2, mitochondrial; Required for mitoribosome formation and stability, and mitochondrial translation; Belongs to the universal ribosomal protein uS2 family. | Tumor protein D52; Belongs to the TPD52 family. | 0.955 |
| MRPS2 | ZNF133 | ENSP00000360850 | ENSP00000439427 | 28S ribosomal protein S2, mitochondrial; Required for mitoribosome formation and stability, and mitochondrial translation; Belongs to the universal ribosomal protein uS2 family. | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor. | 0.853 |
| MRPS7 | DAP3 | ENSP00000245539 | ENSP00000357320 | Mitochondrial ribosomal protein S7. | 28S ribosomal protein S29, mitochondrial; Involved in mediating interferon-gamma-induced cell death; Belongs to the mitochondrion-specific ribosomal protein mS29 family. | 0.999 |
| MRPS7 | MRPS2 | ENSP00000245539 | ENSP00000360850 | Mitochondrial ribosomal protein S7. | 28S ribosomal protein S2, mitochondrial; Required for mitoribosome formation and stability, and mitochondrial translation; Belongs to the universal ribosomal protein uS2 family. | 0.999 |
| MRPS7 | ZNF133 | ENSP00000245539 | ENSP00000439427 | Mitochondrial ribosomal protein S7. | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor. | 0.561 |
| RBBP9 | DZANK1 | ENSP00000336866 | ENSP00000262547 | Serine hydrolase RBBP9; Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1. | Double zinc ribbon and ankyrin repeat domains 1. | 0.612 |
| RBBP9 | ZNF133 | ENSP00000336866 | ENSP00000439427 | Serine hydrolase RBBP9; Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1. | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor. | 0.683 |
| SAV1 | STK4 | ENSP00000324729 | ENSP00000361892 | Protein salvador homolog 1; Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleu [...] | Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] | 0.999 |
| SAV1 | ZNF133 | ENSP00000324729 | ENSP00000439427 | Protein salvador homolog 1; Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleu [...] | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor. | 0.784 |
| STK4 | SAV1 | ENSP00000361892 | ENSP00000324729 | Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] | Protein salvador homolog 1; Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleu [...] | 0.999 |
| STK4 | ZNF133 | ENSP00000361892 | ENSP00000439427 | Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor. | 0.742 |
