Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ZNF234Zinc finger protein 234; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (700 aa)    
Predicted Functional Partners:
ZNF225
Zinc finger protein 225; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
  
  
0.727
ZNF605
Zinc finger protein 605; May be involved in transcriptional regulation.
  
   
0.726
ZNF223
Zinc finger protein 223; May be involved in transcriptional regulation.
  
   
0.594
ZKSCAN5
Zinc finger protein with KRAB and SCAN domains 5; May be involved in transcriptional regulation.
  
   
0.574
ZNF222
Zinc finger protein 222; May be involved in transcriptional regulation.
  
   
0.529
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]
     
 0.501
UBE2H
Ubiquitin-conjugating enzyme E2 H; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.
    
   0.457
ZNF233
Zinc finger protein 233; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
  
   
0.453
ZNF285
Zinc finger protein 285; May be involved in transcriptional regulation.
  
   
0.451
SH2D5
SH2 domain-containing protein 5; May be involved in synaptic plasticity regulation through the control of Rac-GTP levels.
      
 0.444
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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