| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALX1 | ZNF300 | ENSP00000315417 | ENSP00000397178 | ALX homeobox protein 1; Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival. May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1. Belongs to the paired homeobox family. | Zinc finger protein 300; Has a transcriptional repressor activity. | 0.428 |
| DDX39A | TRIM28 | ENSP00000242776 | ENSP00000253024 | ATP-dependent RNA helicase DDX39A; [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus; Belongs to the DEAD box helicase family. DECD subfamily. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.543 |
| DDX39A | ZNF300 | ENSP00000242776 | ENSP00000397178 | ATP-dependent RNA helicase DDX39A; [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus; Belongs to the DEAD box helicase family. DECD subfamily. | Zinc finger protein 300; Has a transcriptional repressor activity. | 0.457 |
| EFNA3 | ZNF300 | ENSP00000357393 | ENSP00000397178 | Ephrin-A3; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). | Zinc finger protein 300; Has a transcriptional repressor activity. | 0.466 |
| IRGM | ZNF300 | ENSP00000428220 | ENSP00000397178 | Immunity-related GTPase family M protein; Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity). Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. | Zinc finger protein 300; Has a transcriptional repressor activity. | 0.814 |
| TRIM28 | DDX39A | ENSP00000253024 | ENSP00000242776 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | ATP-dependent RNA helicase DDX39A; [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus; Belongs to the DEAD box helicase family. DECD subfamily. | 0.543 |
| TRIM28 | ZNF300 | ENSP00000253024 | ENSP00000397178 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 300; Has a transcriptional repressor activity. | 0.568 |
| TRIM28 | ZNF615 | ENSP00000253024 | ENSP00000471041 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 615; May be involved in transcriptional regulation. | 0.717 |
| ZNF300 | ALX1 | ENSP00000397178 | ENSP00000315417 | Zinc finger protein 300; Has a transcriptional repressor activity. | ALX homeobox protein 1; Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival. May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1. Belongs to the paired homeobox family. | 0.428 |
| ZNF300 | DDX39A | ENSP00000397178 | ENSP00000242776 | Zinc finger protein 300; Has a transcriptional repressor activity. | ATP-dependent RNA helicase DDX39A; [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus; Belongs to the DEAD box helicase family. DECD subfamily. | 0.457 |
| ZNF300 | EFNA3 | ENSP00000397178 | ENSP00000357393 | Zinc finger protein 300; Has a transcriptional repressor activity. | Ephrin-A3; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). | 0.466 |
| ZNF300 | IRGM | ENSP00000397178 | ENSP00000428220 | Zinc finger protein 300; Has a transcriptional repressor activity. | Immunity-related GTPase family M protein; Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity). Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. | 0.814 |
| ZNF300 | TRIM28 | ENSP00000397178 | ENSP00000253024 | Zinc finger protein 300; Has a transcriptional repressor activity. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.568 |
| ZNF300 | ZNF615 | ENSP00000397178 | ENSP00000471041 | Zinc finger protein 300; Has a transcriptional repressor activity. | Zinc finger protein 615; May be involved in transcriptional regulation. | 0.519 |
| ZNF300 | ZNF630 | ENSP00000397178 | ENSP00000354683 | Zinc finger protein 300; Has a transcriptional repressor activity. | Zinc finger protein 630; May be involved in transcriptional regulation. | 0.849 |
| ZNF300 | ZNF69 | ENSP00000397178 | ENSP00000345333 | Zinc finger protein 300; Has a transcriptional repressor activity. | Zinc finger protein 69. | 0.481 |
| ZNF615 | TRIM28 | ENSP00000471041 | ENSP00000253024 | Zinc finger protein 615; May be involved in transcriptional regulation. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.717 |
| ZNF615 | ZNF300 | ENSP00000471041 | ENSP00000397178 | Zinc finger protein 615; May be involved in transcriptional regulation. | Zinc finger protein 300; Has a transcriptional repressor activity. | 0.519 |
| ZNF615 | ZNF630 | ENSP00000471041 | ENSP00000354683 | Zinc finger protein 615; May be involved in transcriptional regulation. | Zinc finger protein 630; May be involved in transcriptional regulation. | 0.611 |
| ZNF615 | ZNF69 | ENSP00000471041 | ENSP00000345333 | Zinc finger protein 615; May be involved in transcriptional regulation. | Zinc finger protein 69. | 0.720 |