node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGFR | GRB2 | ENSCAFP00000005164 | ENSCAFP00000049390 | Receptor protein-tyrosine kinase. | Growth factor receptor bound protein 2. | 0.999 |
EGFR | PDGFA | ENSCAFP00000005164 | ENSCAFP00000055011 | Receptor protein-tyrosine kinase. | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. | 0.931 |
EGFR | PDGFB | ENSCAFP00000005164 | ENSCAFP00000056148 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] | 0.935 |
EGFR | PDGFC | ENSCAFP00000005164 | ENSCAFP00000012624 | Receptor protein-tyrosine kinase. | Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.936 |
EGFR | PDGFRB | ENSCAFP00000005164 | ENSCAFP00000000714 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at v [...] | 0.966 |
EGFR | PIK3R1 | ENSCAFP00000005164 | ENSCAFP00000011322 | Receptor protein-tyrosine kinase. | Phosphoinositide-3-kinase regulatory subunit 1. | 0.985 |
EGFR | PLCG1 | ENSCAFP00000005164 | ENSCAFP00000046841 | Receptor protein-tyrosine kinase. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. | 0.982 |
EGFR | PLCG2 | ENSCAFP00000005164 | ENSCAFP00000029622 | Receptor protein-tyrosine kinase. | Phosphoinositide phospholipase C. | 0.963 |
EGFR | PTPN11 | ENSCAFP00000005164 | ENSCAFP00000013074 | Receptor protein-tyrosine kinase. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.990 |
EGFR | SRC | ENSCAFP00000005164 | ENSCAFP00000044994 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase. | 0.989 |
GRB2 | EGFR | ENSCAFP00000049390 | ENSCAFP00000005164 | Growth factor receptor bound protein 2. | Receptor protein-tyrosine kinase. | 0.999 |
GRB2 | PDGFA | ENSCAFP00000049390 | ENSCAFP00000055011 | Growth factor receptor bound protein 2. | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. | 0.450 |
GRB2 | PDGFRB | ENSCAFP00000049390 | ENSCAFP00000000714 | Growth factor receptor bound protein 2. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at v [...] | 0.976 |
GRB2 | PIK3R1 | ENSCAFP00000049390 | ENSCAFP00000011322 | Growth factor receptor bound protein 2. | Phosphoinositide-3-kinase regulatory subunit 1. | 0.948 |
GRB2 | PLCG1 | ENSCAFP00000049390 | ENSCAFP00000046841 | Growth factor receptor bound protein 2. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. | 0.926 |
GRB2 | PLCG2 | ENSCAFP00000049390 | ENSCAFP00000029622 | Growth factor receptor bound protein 2. | Phosphoinositide phospholipase C. | 0.845 |
GRB2 | PTPN11 | ENSCAFP00000049390 | ENSCAFP00000013074 | Growth factor receptor bound protein 2. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.995 |
GRB2 | SRC | ENSCAFP00000049390 | ENSCAFP00000044994 | Growth factor receptor bound protein 2. | Tyrosine-protein kinase. | 0.980 |
PDGFA | EGFR | ENSCAFP00000055011 | ENSCAFP00000005164 | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. | Receptor protein-tyrosine kinase. | 0.931 |
PDGFA | GRB2 | ENSCAFP00000055011 | ENSCAFP00000049390 | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. | Growth factor receptor bound protein 2. | 0.450 |