STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TFAP2BTranscription factor AP-2-beta; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and f [...] (476 aa)    
Predicted Functional Partners:
YEATS4
YEATS domain containing 4.
    
 0.739
KCTD1
Potassium channel tetramerization domain containing 1.
   
 0.687
TFAP4
Transcription factor AP-4.
   
  
 0.678
TFAP2A
Transcription factor AP-2 alpha.
  
0.622
SKOR1
SKI family transcriptional corepressor 1.
      
 0.606
TFAP2D
Transcription factor AP-2 delta.
  
0.596
CITED1
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.
    
 0.595
CITED2
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.
   
 0.592
GPR61
G protein-coupled receptor 61; Belongs to the G-protein coupled receptor 1 family.
      
 0.575
GTF3A
General transcription factor IIIA.
    
 
 0.571
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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