STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAB1ARas-related protein Rab-1A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secreti [...] (205 aa)    
Predicted Functional Partners:
C11H9orf72
Chromosome 11 C9orf72 homolog.
    
 0.921
RAB1B
RAB1B, member RAS oncogene family.
  
 
0.902
USO1
USO1 vesicle transport factor.
   
 0.894
TBC1D20
TBC1 domain family member 20.
    
 0.881
TRAPPC1
Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family.
   
 0.866
TRAPPC8
Trafficking protein particle complex 8.
   
 0.848
STX5
Syntaxin 5; Belongs to the syntaxin family.
    
 0.843
TRAPPC2
Trafficking protein particle complex subunit 2; Prevents ENO1-mediated transcriptional repression and antagonizes ENO1-mediated cell death. May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity).
   
 0.835
TRAPPC3
Trafficking protein particle complex subunit; May play a role in vesicular transport from endoplasmic reticulum to Golgi.
   
 0.829
GBF1
Golgi brefeldin A resistant guanine nucleotide exchange factor 1.
   
 0.825
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (26%) [HD]