STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
INPP5BInositol polyphosphate-5-phosphatase, 75kDa (799 aa)    
Predicted Functional Partners:
OCRL
OCRL, inositol polyphosphate-5-phosphatase; Oculocerebrorenal syndrome of Lowe
   
0.954
PTEN
Canis lupus familiaris phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase [...]
   
 0.927
ENSCAFG00000012631
Uncharacterized protein; Belongs to the small GTPase superfamily. Rho family
   
 0.925
RAC2
Ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Belongs to the small GTPase superfamily. Rho family
   
 0.922
RHOQ
Uncharacterized protein; Ras homolog family member Q; Belongs to the small GTPase superfamily. Rho family
   
 0.922
RHOG
Ras homolog family member G; Belongs to the small GTPase superfamily. Rho family
   
 0.922
RAC3
Uncharacterized protein; Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3); Belongs to the small GTPase superfamily. Rho family
   
 0.922
RHOF
Ras homolog family member F (in filopodia); Belongs to the small GTPase superfamily. Rho family
   
 0.922
RHOBTB2
Rho-related BTB domain containing 2
   
 0.922
RHOD
Ras homolog family member D; Belongs to the small GTPase superfamily. Rho family
   
 0.922
Your Current Organism:
Canis lupus
NCBI taxonomy Id: 9612
Other names: C. lupus, Canis familiaris, Canis lupus, gray wolf, grey wolf
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