Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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TESTestin; Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity); Belongs to the prickle / espinas / testin family. (428 aa)    
Predicted Functional Partners:
VANGL1
Vang-like protein.
    
 0.810
ENAH
ENAH actin regulator.
   
 
 0.810
SERPINB1
Serpin family B member 1; Belongs to the serpin family.
    
 
 0.772
THADA
Thyroid adenoma-associated protein homolog; Belongs to the THADA family.
    
   0.698
ACTL7A
Actin like 7A; Belongs to the actin family.
    
 
 0.688
ZYX
Zyxin.
   
 
 0.674
DVL1
Dishevelled segment polarity protein 1.
    
 0.659
DVL3
Dishevelled segment polarity protein 3.
    
 0.636
J9P328_CANLF
WH1 domain-containing protein.
   
 
 0.595
VASP
Vasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end [...]
   
 
 0.595
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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