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TYR protein (Canis lupus) - STRING interaction network
"TYR" - Tyrosinase in Canis lupus
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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TYRTyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4- dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6- dihydroxyindole) to indole-5,6 quinone; Belongs to the tyrosinase family (530 aa)    
Predicted Functional Partners:
TH
Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons (495 aa)
     
 
  0.943
PMEL
Canis lupus familiaris premelanosome protein (PMEL), mRNA (720 aa)
     
   
  0.932
MITF
Canis lupus familiaris microphthalmia-associated transcription factor (MITF), mRNA (479 aa)
     
 
  0.931
DDC
Dopa decarboxylase (aromatic L-amino acid decarboxylase) (480 aa)
         
  0.922
MLANA
melan-A (118 aa)
     
   
  0.913
OCA2
OCA2 melanosomal transmembrane protein; Oculocutaneous albinism II (726 aa)
     
   
  0.907
GOT1
Aspartate aminotransferase; Glutamic-oxaloacetic transaminase 1, soluble (413 aa)
     
 
  0.905
GOT2
annotation not available (430 aa)
     
 
  0.903
TPO
Thyroid peroxidase; Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4); Belongs to the peroxidase family. XPO subfamily (944 aa)
     
 
  0.903
TAT
Tyrosine aminotransferase (358 aa)
     
 
  0.902
Your Current Organism:
Canis lupus
NCBI taxonomy Id: 9612
Other names: C. lupus, Canis familiaris, Canis lupus, gray wolf, grey wolf
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