node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGFR | GAB2 | ENSCAFP00000005164 | ENSCAFP00000007132 | Receptor protein-tyrosine kinase. | GRB2 associated binding protein 2. | 0.903 |
EGFR | GRB2 | ENSCAFP00000005164 | ENSCAFP00000049390 | Receptor protein-tyrosine kinase. | Growth factor receptor bound protein 2. | 0.999 |
EGFR | LYN | ENSCAFP00000005164 | ENSCAFP00000046785 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase. | 0.604 |
EGFR | PDGFRB | ENSCAFP00000005164 | ENSCAFP00000000714 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at v [...] | 0.966 |
EGFR | PIK3CB | ENSCAFP00000005164 | ENSCAFP00000011245 | Receptor protein-tyrosine kinase. | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. | 0.948 |
EGFR | PLCG2 | ENSCAFP00000005164 | ENSCAFP00000029622 | Receptor protein-tyrosine kinase. | Phosphoinositide phospholipase C. | 0.963 |
EGFR | PTPN11 | ENSCAFP00000005164 | ENSCAFP00000013074 | Receptor protein-tyrosine kinase. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.990 |
EGFR | SOS1 | ENSCAFP00000005164 | ENSCAFP00000009512 | Receptor protein-tyrosine kinase. | SOS Ras/Rac guanine nucleotide exchange factor 1. | 0.996 |
EGFR | SOS2 | ENSCAFP00000005164 | ENSCAFP00000021080 | Receptor protein-tyrosine kinase. | SOS Ras/Rho guanine nucleotide exchange factor 2. | 0.977 |
GAB2 | EGFR | ENSCAFP00000007132 | ENSCAFP00000005164 | GRB2 associated binding protein 2. | Receptor protein-tyrosine kinase. | 0.903 |
GAB2 | GRB2 | ENSCAFP00000007132 | ENSCAFP00000049390 | GRB2 associated binding protein 2. | Growth factor receptor bound protein 2. | 0.945 |
GAB2 | KIT | ENSCAFP00000007132 | ENSCAFP00000003042 | GRB2 associated binding protein 2. | Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] | 0.905 |
GAB2 | LYN | ENSCAFP00000007132 | ENSCAFP00000046785 | GRB2 associated binding protein 2. | Tyrosine-protein kinase. | 0.911 |
GAB2 | PDGFRB | ENSCAFP00000007132 | ENSCAFP00000000714 | GRB2 associated binding protein 2. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at v [...] | 0.903 |
GAB2 | PIK3CB | ENSCAFP00000007132 | ENSCAFP00000011245 | GRB2 associated binding protein 2. | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. | 0.905 |
GAB2 | PLCG2 | ENSCAFP00000007132 | ENSCAFP00000029622 | GRB2 associated binding protein 2. | Phosphoinositide phospholipase C. | 0.905 |
GAB2 | PTPN11 | ENSCAFP00000007132 | ENSCAFP00000013074 | GRB2 associated binding protein 2. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.917 |
GAB2 | SOS1 | ENSCAFP00000007132 | ENSCAFP00000009512 | GRB2 associated binding protein 2. | SOS Ras/Rac guanine nucleotide exchange factor 1. | 0.911 |
GAB2 | SOS2 | ENSCAFP00000007132 | ENSCAFP00000021080 | GRB2 associated binding protein 2. | SOS Ras/Rho guanine nucleotide exchange factor 2. | 0.911 |
GRB2 | EGFR | ENSCAFP00000049390 | ENSCAFP00000005164 | Growth factor receptor bound protein 2. | Receptor protein-tyrosine kinase. | 0.999 |