node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGT | EDN1 | ENSCAFP00000017760 | ENSCAFP00000014389 | Angiotensinogen; Belongs to the serpin family. | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 0.800 |
AGT | EDN2 | ENSCAFP00000017760 | ENSCAFP00000003751 | Angiotensinogen; Belongs to the serpin family. | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | 0.505 |
AGT | EDN3 | ENSCAFP00000017760 | ENSCAFP00000018044 | Angiotensinogen; Belongs to the serpin family. | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides. | 0.476 |
AGT | EDNRA | ENSCAFP00000017760 | ENSCAFP00000011497 | Angiotensinogen; Belongs to the serpin family. | Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). | 0.936 |
AGT | EDNRB | ENSCAFP00000017760 | ENSCAFP00000007760 | Angiotensinogen; Belongs to the serpin family. | Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. | 0.923 |
AGT | GNAQ | ENSCAFP00000017760 | ENSCAFP00000028446 | Angiotensinogen; Belongs to the serpin family. | Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. | 0.588 |
AGT | KNG1 | ENSCAFP00000017760 | ENSCAFP00000020071 | Angiotensinogen; Belongs to the serpin family. | Kininogen 1. | 0.582 |
EDN1 | AGT | ENSCAFP00000014389 | ENSCAFP00000017760 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Angiotensinogen; Belongs to the serpin family. | 0.800 |
EDN1 | EDN2 | ENSCAFP00000014389 | ENSCAFP00000003751 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | 0.924 |
EDN1 | EDN3 | ENSCAFP00000014389 | ENSCAFP00000018044 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides. | 0.938 |
EDN1 | EDNRA | ENSCAFP00000014389 | ENSCAFP00000011497 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). | 0.999 |
EDN1 | EDNRB | ENSCAFP00000014389 | ENSCAFP00000007760 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. | 0.999 |
EDN1 | GNAQ | ENSCAFP00000014389 | ENSCAFP00000028446 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. | 0.585 |
EDN1 | KNG1 | ENSCAFP00000014389 | ENSCAFP00000020071 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Kininogen 1. | 0.707 |
EDN2 | AGT | ENSCAFP00000003751 | ENSCAFP00000017760 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | Angiotensinogen; Belongs to the serpin family. | 0.505 |
EDN2 | EDN1 | ENSCAFP00000003751 | ENSCAFP00000014389 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 0.924 |
EDN2 | EDN3 | ENSCAFP00000003751 | ENSCAFP00000018044 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides. | 0.927 |
EDN2 | EDNRA | ENSCAFP00000003751 | ENSCAFP00000011497 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). | 0.974 |
EDN2 | EDNRB | ENSCAFP00000003751 | ENSCAFP00000007760 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. | 0.991 |
EDN2 | GNAQ | ENSCAFP00000003751 | ENSCAFP00000028446 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. | 0.586 |