STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AKT2AKT serine/threonine kinase 2. (557 aa)    
Predicted Functional Partners:
MTOR
Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.
    
 0.930
FOXO1
Forkhead box O1.
    
 0.914
TSC2
TSC complex subunit 2.
    
 0.904
PDPK1
3-phosphoinositide dependent protein kinase 1.
  
0.894
FOXO4
Forkhead box O4.
    
 0.886
TSC1
TSC complex subunit 1.
    
 0.869
ILK
Integrin linked kinase.
   
 0.868
PHLPP1
PH domain and leucine rich repeat protein phosphatase 1.
    
 0.867
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
   
 0.854
TRIB3
Tribbles pseudokinase 3.
    
 0.853
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.