STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRASKRAS proto-oncogene, GTPase. (283 aa)    
Predicted Functional Partners:
BRAF
B-Raf proto-oncogene, serine/threonine kinase.
   
 0.996
PIK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
   
 0.995
EGFR
Receptor protein-tyrosine kinase.
    
 0.993
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
   
 0.986
NF1
Neurofibromin 1.
   
 0.985
ARAF
A-Raf proto-oncogene, serine/threonine kinase.
    
 0.982
RAF1
Raf-1 proto-oncogene, serine/threonine kinase.
    
 0.979
PIK3R1
Phosphoinositide-3-kinase regulatory subunit 1.
    
 0.975
RGL1
Ral guanine nucleotide dissociation stimulator like 1.
   
 0.975
SRC
Tyrosine-protein kinase.
   
 0.974
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.