node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHSG | APOA2 | ENSCAFP00000019983 | ENSCAFP00000018988 | Alpha 2-HS glycoprotein. | Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. | 0.878 |
AHSG | APOB | ENSCAFP00000019983 | ENSCAFP00000005806 | Alpha 2-HS glycoprotein. | Apolipoprotein B. | 0.825 |
AHSG | APOC3 | ENSCAFP00000019983 | ENSCAFP00000019635 | Alpha 2-HS glycoprotein. | Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] | 0.796 |
AHSG | APOH | ENSCAFP00000019983 | ENSCAFP00000016597 | Alpha 2-HS glycoprotein. | Beta-2-glycoprotein 1; Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. | 0.937 |
AHSG | FABP1 | ENSCAFP00000019983 | ENSCAFP00000011015 | Alpha 2-HS glycoprotein. | FABP domain-containing protein. | 0.857 |
AHSG | FGG | ENSCAFP00000019983 | ENSCAFP00000012417 | Alpha 2-HS glycoprotein. | Fibrinogen gamma chain; Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhan [...] | 0.898 |
APOA2 | AHSG | ENSCAFP00000018988 | ENSCAFP00000019983 | Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. | Alpha 2-HS glycoprotein. | 0.878 |
APOA2 | APOB | ENSCAFP00000018988 | ENSCAFP00000005806 | Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. | Apolipoprotein B. | 0.960 |
APOA2 | APOC3 | ENSCAFP00000018988 | ENSCAFP00000019635 | Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. | Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] | 0.994 |
APOA2 | APOH | ENSCAFP00000018988 | ENSCAFP00000016597 | Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. | Beta-2-glycoprotein 1; Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. | 0.953 |
APOA2 | FABP1 | ENSCAFP00000018988 | ENSCAFP00000011015 | Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. | FABP domain-containing protein. | 0.647 |
APOA2 | FGG | ENSCAFP00000018988 | ENSCAFP00000012417 | Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. | Fibrinogen gamma chain; Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhan [...] | 0.727 |
APOB | AHSG | ENSCAFP00000005806 | ENSCAFP00000019983 | Apolipoprotein B. | Alpha 2-HS glycoprotein. | 0.825 |
APOB | APOA2 | ENSCAFP00000005806 | ENSCAFP00000018988 | Apolipoprotein B. | Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. | 0.960 |
APOB | APOC3 | ENSCAFP00000005806 | ENSCAFP00000019635 | Apolipoprotein B. | Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] | 0.968 |
APOB | APOH | ENSCAFP00000005806 | ENSCAFP00000016597 | Apolipoprotein B. | Beta-2-glycoprotein 1; Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. | 0.812 |
APOB | FABP1 | ENSCAFP00000005806 | ENSCAFP00000011015 | Apolipoprotein B. | FABP domain-containing protein. | 0.819 |
APOB | FGG | ENSCAFP00000005806 | ENSCAFP00000012417 | Apolipoprotein B. | Fibrinogen gamma chain; Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhan [...] | 0.651 |
APOB | PPARA | ENSCAFP00000005806 | ENSCAFP00000054067 | Apolipoprotein B. | Peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and [...] | 0.576 |
APOC3 | AHSG | ENSCAFP00000019635 | ENSCAFP00000019983 | Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] | Alpha 2-HS glycoprotein. | 0.796 |