Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MAPKAPK5MAPK activated protein kinase 5; Belongs to the aldehyde dehydrogenase family. (972 aa)    
Predicted Functional Partners:
ACADS
Acyl-CoA dehydrogenase short chain.
   
 
 0.831
PCCB
Propionyl-CoA carboxylase subunit beta.
   
 
 0.821
ACSS1
Acetyl-coenzyme A synthetase.
   
 0.815
ABAT
4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.811
ALDH6A1
Aldehyde dehydrogenase 6 family member A1.
   
 0.809
AKR1A1
Aldo_ket_red domain-containing protein.
   
 0.806
ACSS2
Acyl-CoA synthetase short chain family member 2.
   
 0.805
DBT
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.
   
 
 0.784
MAOB
Amine oxidase [flavin-containing] B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity).
   
 0.780
AGXT2
Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.779
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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