STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MT2AMetallothionein-2; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. (268 aa)    
Predicted Functional Partners:
SLC30A1
Solute carrier family 30 member 1.
   
  
 0.471
MT1E
Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.
  
  
0.468
FKBP1B
Peptidylprolyl isomerase.
   
  
 0.448
CCS
Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.
   
  
 0.438
CP
Ceruloplasmin; Belongs to the multicopper oxidase family.
   
  
 0.438
ATP7B
ATPase copper transporting beta.
      
 0.432
LOC611632
Uncharacterized protein; Belongs to the multicopper oxidase family.
      
 0.428
DDIT4
DNA damage inducible transcript 4.
   
  
 0.424
UBASH3B
Ubiquitin associated and SH3 domain containing B.
      
 0.414
ATOX1
Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity); Belongs to the ATX1 family.
   
  
 0.403
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.