| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATP2A2 | CALML5 | ENSCAFP00000050835 | ENSCAFP00000007824 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] | Calmodulin like 5. | 0.550 |
| ATP2A2 | CALML6 | ENSCAFP00000050835 | ENSCAFP00000028340 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] | Calmodulin like 6. | 0.528 |
| ATP2A2 | PPP3CC | ENSCAFP00000050835 | ENSCAFP00000041292 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] | Serine/threonine-protein phosphatase. | 0.919 |
| ATP2A2 | PPP3R1 | ENSCAFP00000050835 | ENSCAFP00000065679 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] | Uncharacterized protein. | 0.910 |
| CALML5 | ATP2A2 | ENSCAFP00000007824 | ENSCAFP00000050835 | Calmodulin like 5. | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] | 0.550 |
| CALML5 | CALML6 | ENSCAFP00000007824 | ENSCAFP00000028340 | Calmodulin like 5. | Calmodulin like 6. | 0.735 |
| CALML5 | NFATC1 | ENSCAFP00000007824 | ENSCAFP00000031585 | Calmodulin like 5. | Nuclear factor of activated T cells 1. | 0.469 |
| CALML5 | NFATC4 | ENSCAFP00000007824 | ENSCAFP00000039115 | Calmodulin like 5. | Nuclear factor of activated T cells 4. | 0.449 |
| CALML5 | PPP3CC | ENSCAFP00000007824 | ENSCAFP00000041292 | Calmodulin like 5. | Serine/threonine-protein phosphatase. | 0.919 |
| CALML5 | PPP3R1 | ENSCAFP00000007824 | ENSCAFP00000065679 | Calmodulin like 5. | Uncharacterized protein. | 0.891 |
| CALML6 | ATP2A2 | ENSCAFP00000028340 | ENSCAFP00000050835 | Calmodulin like 6. | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] | 0.528 |
| CALML6 | CALML5 | ENSCAFP00000028340 | ENSCAFP00000007824 | Calmodulin like 6. | Calmodulin like 5. | 0.735 |
| CALML6 | NFATC1 | ENSCAFP00000028340 | ENSCAFP00000031585 | Calmodulin like 6. | Nuclear factor of activated T cells 1. | 0.580 |
| CALML6 | NFATC2 | ENSCAFP00000028340 | ENSCAFP00000017095 | Calmodulin like 6. | Nuclear factor of activated T cells 2. | 0.503 |
| CALML6 | NFATC4 | ENSCAFP00000028340 | ENSCAFP00000039115 | Calmodulin like 6. | Nuclear factor of activated T cells 4. | 0.495 |
| CALML6 | PPP3CC | ENSCAFP00000028340 | ENSCAFP00000041292 | Calmodulin like 6. | Serine/threonine-protein phosphatase. | 0.914 |
| CALML6 | PPP3R1 | ENSCAFP00000028340 | ENSCAFP00000065679 | Calmodulin like 6. | Uncharacterized protein. | 0.907 |
| CRTC2 | PPP3CC | ENSCAFP00000025646 | ENSCAFP00000041292 | CREB regulated transcription coactivator 2. | Serine/threonine-protein phosphatase. | 0.925 |
| CRTC2 | PPP3R1 | ENSCAFP00000025646 | ENSCAFP00000065679 | CREB regulated transcription coactivator 2. | Uncharacterized protein. | 0.931 |
| GSK3B | NFATC1 | ENSCAFP00000034412 | ENSCAFP00000031585 | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. | Nuclear factor of activated T cells 1. | 0.926 |
