MAPK10 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MAPK10

Mitogen-activated protein kinase. (467 aa)

Predicted Functional Partners:

MAPK9

0.983

FOSL1

0.977

MAP2K4

0.964

MAPK8IP1

0.963

MAP2K7

0.958

TP53

0.958

MAP3K1

0.952

BCL2L1

0.949

ELK1

0.947

MAPK8IP3

0.944

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2L1	MAPK10	ENSCAFP00000010478	ENSCAFP00000013847	BCL2 like 1.	Mitogen-activated protein kinase.	0.949
BCL2L1	MAPK9	ENSCAFP00000010478	ENSCAFP00000063065	BCL2 like 1.	Mitogen-activated protein kinase.	0.937
BCL2L1	TP53	ENSCAFP00000010478	ENSCAFP00000064590	BCL2 like 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.991
ELK1	MAPK10	ENSCAFP00000022360	ENSCAFP00000013847	ETS transcription factor ELK1.	Mitogen-activated protein kinase.	0.947
ELK1	MAPK9	ENSCAFP00000022360	ENSCAFP00000063065	ETS transcription factor ELK1.	Mitogen-activated protein kinase.	0.972
FOSL1	MAPK10	ENSCAFP00000019360	ENSCAFP00000013847	FOS like 1, AP-1 transcription factor subunit.	Mitogen-activated protein kinase.	0.977
FOSL1	MAPK9	ENSCAFP00000019360	ENSCAFP00000063065	FOS like 1, AP-1 transcription factor subunit.	Mitogen-activated protein kinase.	0.914
MAP2K4	MAP2K7	ENSCAFP00000049330	ENSCAFP00000040122	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 7.	0.963
MAP2K4	MAP3K1	ENSCAFP00000049330	ENSCAFP00000043507	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase 1.	0.991
MAP2K4	MAPK10	ENSCAFP00000049330	ENSCAFP00000013847	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.964
MAP2K4	MAPK8IP3	ENSCAFP00000049330	ENSCAFP00000039314	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase 8 interacting protein 3.	0.977
MAP2K4	MAPK9	ENSCAFP00000049330	ENSCAFP00000063065	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.993
MAP2K7	MAP2K4	ENSCAFP00000040122	ENSCAFP00000049330	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	0.963
MAP2K7	MAP3K1	ENSCAFP00000040122	ENSCAFP00000043507	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase kinase kinase 1.	0.994
MAP2K7	MAPK10	ENSCAFP00000040122	ENSCAFP00000013847	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase.	0.958
MAP2K7	MAPK8IP1	ENSCAFP00000040122	ENSCAFP00000054941	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase 8 interacting protein 1.	0.984
MAP2K7	MAPK8IP3	ENSCAFP00000040122	ENSCAFP00000039314	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase 8 interacting protein 3.	0.984
MAP2K7	MAPK9	ENSCAFP00000040122	ENSCAFP00000063065	Mitogen-activated protein kinase kinase 7.	Mitogen-activated protein kinase.	0.991
MAP3K1	MAP2K4	ENSCAFP00000043507	ENSCAFP00000049330	Mitogen-activated protein kinase kinase kinase 1.	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	0.991
MAP3K1	MAP2K7	ENSCAFP00000043507	ENSCAFP00000040122	Mitogen-activated protein kinase kinase kinase 1.	Mitogen-activated protein kinase kinase 7.	0.994