STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SFTPCPulmonary surfactant-associated protein C. (314 aa)    
Predicted Functional Partners:
SFTPD
Surfactant protein D.
   
 
 0.967
LOC610540
Pulmonary surfactant-associated protein A; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages; Belongs to the SFTPA family.
   
 
 0.966
SFTPB
Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
   
  
 0.959
SCGB1A1
Secretoglobin family 1A member 1.
   
  
 0.927
NAPSA
Napsin A aspartic peptidase; Belongs to the peptidase A1 family.
   
 
 0.890
AGER
Advanced glycosylation end product-specific receptor variant C.
   
  
 0.884
SCGB3A2
Secretoglobin family 3A member 2.
   
  
 0.841
CTSH
Cathepsin H; Belongs to the peptidase C1 family.
   
 
 0.841
FOXJ1
Forkhead box J1.
      
 0.827
ADGRF5
Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family.
   
 
 0.816
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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