CASQ2 protein (Canis lupus familiaris) - STRING interaction network

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CASQ2

Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. (554 aa)

Predicted Functional Partners:

TRDN

0.994

RYR2

0.991

RYR1

0.960

RYR3

0.937

ASPH

0.929

CASQ1

0.895

SRL

0.832

MYOZ1

0.753

CALML5

0.713

MYOZ2

0.713

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASPH	CASQ1	ENSCAFP00000046486	ENSCAFP00000040392	Aspartate beta-hydroxylase.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.942
ASPH	CASQ2	ENSCAFP00000046486	ENSCAFP00000051055	Aspartate beta-hydroxylase.	Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.	0.929
ASPH	RYR1	ENSCAFP00000046486	ENSCAFP00000008828	Aspartate beta-hydroxylase.	Ryanodine receptor 1.	0.973
ASPH	RYR2	ENSCAFP00000046486	ENSCAFP00000014764	Aspartate beta-hydroxylase.	Ryanodine receptor 2.	0.981
ASPH	RYR3	ENSCAFP00000046486	ENSCAFP00000012007	Aspartate beta-hydroxylase.	Ryanodine receptor 3.	0.921
ASPH	TRDN	ENSCAFP00000046486	ENSCAFP00000001442	Aspartate beta-hydroxylase.	Triadin; Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.	0.977
CALML5	CASQ1	ENSCAFP00000007824	ENSCAFP00000040392	Calmodulin like 5.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.784
CALML5	CASQ2	ENSCAFP00000007824	ENSCAFP00000051055	Calmodulin like 5.	Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.	0.713
CALML5	RYR1	ENSCAFP00000007824	ENSCAFP00000008828	Calmodulin like 5.	Ryanodine receptor 1.	0.956
CALML5	RYR2	ENSCAFP00000007824	ENSCAFP00000014764	Calmodulin like 5.	Ryanodine receptor 2.	0.978
CALML5	RYR3	ENSCAFP00000007824	ENSCAFP00000012007	Calmodulin like 5.	Ryanodine receptor 3.	0.946
CALML5	TRDN	ENSCAFP00000007824	ENSCAFP00000001442	Calmodulin like 5.	Triadin; Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.	0.642
CASQ1	ASPH	ENSCAFP00000040392	ENSCAFP00000046486	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Aspartate beta-hydroxylase.	0.942
CASQ1	CALML5	ENSCAFP00000040392	ENSCAFP00000007824	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calmodulin like 5.	0.784
CASQ1	CASQ2	ENSCAFP00000040392	ENSCAFP00000051055	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.	0.895
CASQ1	MYOZ1	ENSCAFP00000040392	ENSCAFP00000021870	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Calsarcin 2.	0.799
CASQ1	MYOZ2	ENSCAFP00000040392	ENSCAFP00000018306	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Myozenin 2.	0.618
CASQ1	RYR1	ENSCAFP00000040392	ENSCAFP00000008828	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Ryanodine receptor 1.	0.972
CASQ1	RYR2	ENSCAFP00000040392	ENSCAFP00000014764	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Ryanodine receptor 2.	0.985
CASQ1	RYR3	ENSCAFP00000040392	ENSCAFP00000012007	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Ryanodine receptor 3.	0.946

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