SNCA protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	HSPA4	ENSCAFP00000012583	ENSCAFP00000062263	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Heat shock 70 kDa protein 4.	0.516
APP	MAPT	ENSCAFP00000012583	ENSCAFP00000046670	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Microtubule-associated protein.	0.981
APP	PINK1	ENSCAFP00000012583	ENSCAFP00000057576	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	PTEN induced kinase 1.	0.450
APP	PRKN	ENSCAFP00000012583	ENSCAFP00000050441	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.737
APP	SNCA	ENSCAFP00000012583	ENSCAFP00000057557	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Alpha-synuclein; Belongs to the synuclein family.	0.978
APP	TH	ENSCAFP00000012583	ENSCAFP00000014845	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons.	0.441
HSPA4	APP	ENSCAFP00000062263	ENSCAFP00000012583	Heat shock 70 kDa protein 4.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.516
HSPA4	MAPT	ENSCAFP00000062263	ENSCAFP00000046670	Heat shock 70 kDa protein 4.	Microtubule-associated protein.	0.938
HSPA4	PARK7	ENSCAFP00000062263	ENSCAFP00000062561	Heat shock 70 kDa protein 4.	Parkinsonism associated deglycase.	0.783
HSPA4	PINK1	ENSCAFP00000062263	ENSCAFP00000057576	Heat shock 70 kDa protein 4.	PTEN induced kinase 1.	0.659
HSPA4	PRKN	ENSCAFP00000062263	ENSCAFP00000050441	Heat shock 70 kDa protein 4.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.950
HSPA4	SNCA	ENSCAFP00000062263	ENSCAFP00000057557	Heat shock 70 kDa protein 4.	Alpha-synuclein; Belongs to the synuclein family.	0.962
MAPT	APP	ENSCAFP00000046670	ENSCAFP00000012583	Microtubule-associated protein.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.981
MAPT	HSPA4	ENSCAFP00000046670	ENSCAFP00000062263	Microtubule-associated protein.	Heat shock 70 kDa protein 4.	0.938
MAPT	PARK7	ENSCAFP00000046670	ENSCAFP00000062561	Microtubule-associated protein.	Parkinsonism associated deglycase.	0.701
MAPT	PINK1	ENSCAFP00000046670	ENSCAFP00000057576	Microtubule-associated protein.	PTEN induced kinase 1.	0.507
MAPT	PRKN	ENSCAFP00000046670	ENSCAFP00000050441	Microtubule-associated protein.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.904
MAPT	SNCA	ENSCAFP00000046670	ENSCAFP00000057557	Microtubule-associated protein.	Alpha-synuclein; Belongs to the synuclein family.	0.987
PARK7	HSPA4	ENSCAFP00000062561	ENSCAFP00000062263	Parkinsonism associated deglycase.	Heat shock 70 kDa protein 4.	0.783
PARK7	MAPT	ENSCAFP00000062561	ENSCAFP00000046670	Parkinsonism associated deglycase.	Microtubule-associated protein.	0.701