STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TFF2Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity). (170 aa)    
Predicted Functional Partners:
CBLIF
Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity).
   
  
 0.819
ZG16
Zymogen granule protein 16.
   
  
 0.794
MUC6
Uncharacterized protein.
   
  
 0.760
CLPS
Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
   
  
 0.722
MUC5AC
Uncharacterized protein.
   
  
 0.644
LOC478220
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
   
  
 0.613
GKN2
Gastrokine 2.
   
  
 0.600
PNLIP
Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.
   
  
 0.599
CUZD1
CUB and zona pellucida like domains 1.
   
 
 0.576
LOC478196
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
   
    0.569
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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