node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASR | PTH | ENSCAFP00000017381 | ENSCAFP00000053878 | Calcium-sensing receptor. | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). | 0.885 |
CASR | PTH1R | ENSCAFP00000017381 | ENSCAFP00000057719 | Calcium-sensing receptor. | Parathyroid hormone/parathyroid hormone-related peptide receptor; Receptor for parathyroid hormone and for parathyroid hormone- related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. | 0.401 |
CASR | PTHLH | ENSCAFP00000017381 | ENSCAFP00000016137 | Calcium-sensing receptor. | Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teethRequired for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of [...] | 0.560 |
COL10A1 | MMP13 | ENSCAFP00000039411 | ENSCAFP00000022174 | Collagen type X alpha 1 chain. | Matrix metallopeptidase 13. | 0.800 |
COL10A1 | PTH1R | ENSCAFP00000039411 | ENSCAFP00000057719 | Collagen type X alpha 1 chain. | Parathyroid hormone/parathyroid hormone-related peptide receptor; Receptor for parathyroid hormone and for parathyroid hormone- related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. | 0.616 |
COL10A1 | PTHLH | ENSCAFP00000039411 | ENSCAFP00000016137 | Collagen type X alpha 1 chain. | Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teethRequired for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of [...] | 0.591 |
COL10A1 | RUNX2 | ENSCAFP00000039411 | ENSCAFP00000042290 | Collagen type X alpha 1 chain. | RUNX family transcription factor 2. | 0.764 |
COL10A1 | SHH | ENSCAFP00000039411 | ENSCAFP00000050657 | Collagen type X alpha 1 chain. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.517 |
KPNB1 | PTHLH | ENSCAFP00000044873 | ENSCAFP00000016137 | Karyopherin subunit beta 1. | Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teethRequired for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of [...] | 0.872 |
MMP13 | COL10A1 | ENSCAFP00000022174 | ENSCAFP00000039411 | Matrix metallopeptidase 13. | Collagen type X alpha 1 chain. | 0.800 |
MMP13 | PTHLH | ENSCAFP00000022174 | ENSCAFP00000016137 | Matrix metallopeptidase 13. | Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teethRequired for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of [...] | 0.576 |
MMP13 | RUNX2 | ENSCAFP00000022174 | ENSCAFP00000042290 | Matrix metallopeptidase 13. | RUNX family transcription factor 2. | 0.717 |
MMP13 | SHH | ENSCAFP00000022174 | ENSCAFP00000050657 | Matrix metallopeptidase 13. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.587 |
PTH | CASR | ENSCAFP00000053878 | ENSCAFP00000017381 | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). | Calcium-sensing receptor. | 0.885 |
PTH | PTH1R | ENSCAFP00000053878 | ENSCAFP00000057719 | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). | Parathyroid hormone/parathyroid hormone-related peptide receptor; Receptor for parathyroid hormone and for parathyroid hormone- related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. | 0.999 |
PTH | PTH2 | ENSCAFP00000053878 | ENSCAFP00000005465 | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). | Parathyroid hormone 2. | 0.949 |
PTH | PTH2R | ENSCAFP00000053878 | ENSCAFP00000020180 | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). | Parathyroid hormone 2 receptor; Belongs to the G-protein coupled receptor 2 family. | 0.897 |
PTH | PTHLH | ENSCAFP00000053878 | ENSCAFP00000016137 | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). | Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teethRequired for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of [...] | 0.955 |
PTH | RUNX2 | ENSCAFP00000053878 | ENSCAFP00000042290 | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). | RUNX family transcription factor 2. | 0.671 |
PTH1R | CASR | ENSCAFP00000057719 | ENSCAFP00000017381 | Parathyroid hormone/parathyroid hormone-related peptide receptor; Receptor for parathyroid hormone and for parathyroid hormone- related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. | Calcium-sensing receptor. | 0.401 |