node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | ADAMTS4 | ENSCAFP00000065577 | ENSCAFP00000018886 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | ADAM metallopeptidase with thrombospondin type 1 motif 4. | 0.919 |
ACAN | ADAMTS5 | ENSCAFP00000065577 | ENSCAFP00000012608 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | ADAM metallopeptidase with thrombospondin type 1 motif 5. | 0.906 |
ACAN | BGN | ENSCAFP00000065577 | ENSCAFP00000028297 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.874 |
ACAN | COL2A1 | ENSCAFP00000065577 | ENSCAFP00000013330 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Collagen type II alpha 1 chain. | 0.953 |
ACAN | COMP | ENSCAFP00000065577 | ENSCAFP00000055935 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Cartilage oligomeric matrix protein. | 0.910 |
ACAN | DCN | ENSCAFP00000065577 | ENSCAFP00000009230 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.904 |
ACAN | FMOD | ENSCAFP00000065577 | ENSCAFP00000013913 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Fibromodulin. | 0.837 |
ACAN | MMP13 | ENSCAFP00000065577 | ENSCAFP00000022174 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Matrix metallopeptidase 13. | 0.928 |
ACAN | MMP3 | ENSCAFP00000065577 | ENSCAFP00000022195 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase (By similarity); Belongs to the peptidase M10A family. | 0.895 |
ACAN | TNR | ENSCAFP00000065577 | ENSCAFP00000036108 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Tenascin R. | 0.872 |
ADAMTS4 | ACAN | ENSCAFP00000018886 | ENSCAFP00000065577 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.919 |
ADAMTS4 | BGN | ENSCAFP00000018886 | ENSCAFP00000028297 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.536 |
ADAMTS4 | COL2A1 | ENSCAFP00000018886 | ENSCAFP00000013330 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Collagen type II alpha 1 chain. | 0.752 |
ADAMTS4 | COMP | ENSCAFP00000018886 | ENSCAFP00000055935 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Cartilage oligomeric matrix protein. | 0.544 |
ADAMTS4 | DCN | ENSCAFP00000018886 | ENSCAFP00000009230 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.530 |
ADAMTS4 | FMOD | ENSCAFP00000018886 | ENSCAFP00000013913 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Fibromodulin. | 0.483 |
ADAMTS4 | MMP13 | ENSCAFP00000018886 | ENSCAFP00000022174 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Matrix metallopeptidase 13. | 0.893 |
ADAMTS4 | MMP3 | ENSCAFP00000018886 | ENSCAFP00000022195 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase (By similarity); Belongs to the peptidase M10A family. | 0.870 |
ADAMTS5 | ACAN | ENSCAFP00000012608 | ENSCAFP00000065577 | ADAM metallopeptidase with thrombospondin type 1 motif 5. | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.906 |
ADAMTS5 | BGN | ENSCAFP00000012608 | ENSCAFP00000028297 | ADAM metallopeptidase with thrombospondin type 1 motif 5. | Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.467 |