Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ANPEPAminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...] (975 aa)    
Predicted Functional Partners:
PREP
Prolyl endopeptidase.
  
 
 0.928
LAP3
Leucine aminopeptidase 3.
   
 0.926
GGT6
Gamma-glutamyltransferase 6.
     
 0.925
ENPEP
Aminopeptidase.
  
0.920
DPP4
Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.
   
  
 0.913
GGT1
Uncharacterized protein.
     
 0.911
GCLC
Glutamate-cysteine ligase catalytic subunit.
   
 
 0.905
GOT1
Aspartate aminotransferase.
   
 0.902
GOT1L1
Glutamic-oxaloacetic transaminase 1 like 1.
   
 0.898
GSS
Glutathione synthetase.
     
 0.895
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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