STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CTSKCathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. (446 aa)    
Predicted Functional Partners:
AHR
Aryl hydrocarbon receptor.
   
 
 0.906
ARNTL
Aryl hydrocarbon receptor nuclear translocator like.
     
 0.904
ARNTL2
Aryl hydrocarbon receptor nuclear translocator like 2.
     
 0.903
AHRR
Aryl-hydrocarbon receptor repressor.
   
 
 0.902
ARNT
Aryl hydrocarbon receptor nuclear translocator.
     
  0.900
CTSB
Cathepsin B; Belongs to the peptidase C1 family.
   
0.885
CD74
CD74 molecule.
   
 0.884
NFATC1
Nuclear factor of activated T cells 1.
   
  
 0.834
CTSH
Cathepsin H; Belongs to the peptidase C1 family.
  
0.801
IL10RA
Interleukin 10 receptor subunit alpha.
   
 
 0.795
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.