EDN3 protein (Canis lupus familiaris) - STRING interaction network

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Score

EDN3

Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides. (209 aa)

Predicted Functional Partners:

EDNRB

0.999

EDNRA

0.993

EDN1

0.938

EDN2

0.927

AGTR2

0.855

AGTR1

0.854

KEL

0.826

SOX10

0.757

OXTR

0.754

XK

0.750

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGTR1	AGTR2	ENSCAFP00000040421	ENSCAFP00000026975	Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family.	0.937
AGTR1	EDN1	ENSCAFP00000040421	ENSCAFP00000014389	Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.808
AGTR1	EDN2	ENSCAFP00000040421	ENSCAFP00000003751	Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	0.886
AGTR1	EDN3	ENSCAFP00000040421	ENSCAFP00000018044	Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.	Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides.	0.854
AGTR1	EDNRA	ENSCAFP00000040421	ENSCAFP00000011497	Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.	Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).	0.566
AGTR1	EDNRB	ENSCAFP00000040421	ENSCAFP00000007760	Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.	Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.	0.596
AGTR2	AGTR1	ENSCAFP00000026975	ENSCAFP00000040421	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family.	Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.	0.937
AGTR2	EDN1	ENSCAFP00000026975	ENSCAFP00000014389	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.928
AGTR2	EDN2	ENSCAFP00000026975	ENSCAFP00000003751	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family.	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	0.942
AGTR2	EDN3	ENSCAFP00000026975	ENSCAFP00000018044	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family.	Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides.	0.855
AGTR2	EDNRA	ENSCAFP00000026975	ENSCAFP00000011497	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family.	Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).	0.729
AGTR2	EDNRB	ENSCAFP00000026975	ENSCAFP00000007760	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.	0.732
EDN1	AGTR1	ENSCAFP00000014389	ENSCAFP00000040421	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.	0.808
EDN1	AGTR2	ENSCAFP00000014389	ENSCAFP00000026975	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family.	0.928
EDN1	EDN2	ENSCAFP00000014389	ENSCAFP00000003751	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	0.924
EDN1	EDN3	ENSCAFP00000014389	ENSCAFP00000018044	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides.	0.938
EDN1	EDNRA	ENSCAFP00000014389	ENSCAFP00000011497	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).	0.999
EDN1	EDNRB	ENSCAFP00000014389	ENSCAFP00000007760	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.	0.999
EDN1	OXTR	ENSCAFP00000014389	ENSCAFP00000008302	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	0.762
EDN2	AGTR1	ENSCAFP00000003751	ENSCAFP00000040421	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.	0.886