node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | ADAMTS4 | ENSCAFP00000065577 | ENSCAFP00000018886 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | ADAM metallopeptidase with thrombospondin type 1 motif 4. | 0.919 |
ACAN | BCAN | ENSCAFP00000065577 | ENSCAFP00000024595 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Uncharacterized protein. | 0.587 |
ACAN | COL2A1 | ENSCAFP00000065577 | ENSCAFP00000013330 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Collagen type II alpha 1 chain. | 0.953 |
ACAN | IL1B | ENSCAFP00000065577 | ENSCAFP00000010762 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.754 |
ACAN | IL6 | ENSCAFP00000065577 | ENSCAFP00000053025 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.674 |
ACAN | MMP1 | ENSCAFP00000065577 | ENSCAFP00000038708 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Matrix metallopeptidase 1. | 0.626 |
ACAN | MMP13 | ENSCAFP00000065577 | ENSCAFP00000022174 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Matrix metallopeptidase 13. | 0.928 |
ACAN | MMP3 | ENSCAFP00000065577 | ENSCAFP00000022195 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase (By similarity); Belongs to the peptidase M10A family. | 0.895 |
ACAN | MMP9 | ENSCAFP00000065577 | ENSCAFP00000035167 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). | 0.698 |
ACAN | TIMP3 | ENSCAFP00000065577 | ENSCAFP00000040576 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | TIMP metallopeptidase inhibitor 3. | 0.602 |
ADAMTS4 | ACAN | ENSCAFP00000018886 | ENSCAFP00000065577 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.919 |
ADAMTS4 | BCAN | ENSCAFP00000018886 | ENSCAFP00000024595 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Uncharacterized protein. | 0.895 |
ADAMTS4 | COL2A1 | ENSCAFP00000018886 | ENSCAFP00000013330 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Collagen type II alpha 1 chain. | 0.752 |
ADAMTS4 | IL1B | ENSCAFP00000018886 | ENSCAFP00000010762 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.685 |
ADAMTS4 | IL6 | ENSCAFP00000018886 | ENSCAFP00000053025 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.658 |
ADAMTS4 | MMP1 | ENSCAFP00000018886 | ENSCAFP00000038708 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Matrix metallopeptidase 1. | 0.582 |
ADAMTS4 | MMP13 | ENSCAFP00000018886 | ENSCAFP00000022174 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Matrix metallopeptidase 13. | 0.893 |
ADAMTS4 | MMP3 | ENSCAFP00000018886 | ENSCAFP00000022195 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase (By similarity); Belongs to the peptidase M10A family. | 0.870 |
ADAMTS4 | MMP9 | ENSCAFP00000018886 | ENSCAFP00000035167 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). | 0.662 |
ADAMTS4 | TIMP3 | ENSCAFP00000018886 | ENSCAFP00000040576 | ADAM metallopeptidase with thrombospondin type 1 motif 4. | TIMP metallopeptidase inhibitor 3. | 0.611 |