STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PNNPinin; Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation [...] (767 aa)    
Predicted Functional Partners:
RNPS1
RNA binding protein with serine rich domain 1.
   
 0.963
SAP18
Sin3A associated protein 18.
    
 0.960
ACIN1
Apoptotic chromatin condensation inducer 1.
   
 0.916
PNISR
PNN interacting serine and arginine rich protein.
   
 
 0.909
EIF4A3
Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family.
   
 0.883
PRPF4B
Pre-mRNA processing factor 4B.
   
 0.878
TRAPPC6B
Trafficking protein particle complex 6B.
   
  
 0.875
LRFN5
Leucine rich repeat and fibronectin type III domain containing 5.
      
 0.856
LUC7L3
LUC7 like 3 pre-mRNA splicing factor.
   
 
 0.854
RBM39
RNA binding motif protein 39.
   
 0.830
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.