node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARRB1 | ARRB2 | ENSCAFP00000056636 | ENSCAFP00000053738 | Arrestin beta 1. | Arrestin beta 2. | 0.903 |
ARRB1 | DRD2 | ENSCAFP00000056636 | ENSCAFP00000020466 | Arrestin beta 1. | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | 0.944 |
ARRB2 | ARRB1 | ENSCAFP00000053738 | ENSCAFP00000056636 | Arrestin beta 2. | Arrestin beta 1. | 0.903 |
ARRB2 | DRD2 | ENSCAFP00000053738 | ENSCAFP00000020466 | Arrestin beta 2. | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | 0.944 |
CNR1 | DRD2 | ENSCAFP00000004587 | ENSCAFP00000020466 | Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | 0.929 |
CNR1 | GNAI1 | ENSCAFP00000004587 | ENSCAFP00000024156 | Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] | G protein subunit alpha i1. | 0.928 |
CNR1 | GNAI2 | ENSCAFP00000004587 | ENSCAFP00000033576 | Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] | Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). | 0.928 |
CNR1 | GNAI3 | ENSCAFP00000004587 | ENSCAFP00000029356 | Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] | G protein subunit alpha i3. | 0.928 |
DRD2 | ARRB1 | ENSCAFP00000020466 | ENSCAFP00000056636 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | Arrestin beta 1. | 0.944 |
DRD2 | ARRB2 | ENSCAFP00000020466 | ENSCAFP00000053738 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | Arrestin beta 2. | 0.944 |
DRD2 | CNR1 | ENSCAFP00000020466 | ENSCAFP00000004587 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] | 0.929 |
DRD2 | DRD5 | ENSCAFP00000020466 | ENSCAFP00000023019 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. | 0.933 |
DRD2 | GHRL | ENSCAFP00000020466 | ENSCAFP00000007641 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. | 0.963 |
DRD2 | GNAI1 | ENSCAFP00000020466 | ENSCAFP00000024156 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | G protein subunit alpha i1. | 0.958 |
DRD2 | GNAI2 | ENSCAFP00000020466 | ENSCAFP00000033576 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). | 0.958 |
DRD2 | GNAI3 | ENSCAFP00000020466 | ENSCAFP00000029356 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | G protein subunit alpha i3. | 0.958 |
DRD2 | NPY | ENSCAFP00000020466 | ENSCAFP00000004135 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | Neuropeptide Y. | 0.948 |
DRD2 | SST | ENSCAFP00000020466 | ENSCAFP00000064277 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin. | 0.947 |
DRD5 | DRD2 | ENSCAFP00000023019 | ENSCAFP00000020466 | Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | 0.933 |
GHRL | DRD2 | ENSCAFP00000007641 | ENSCAFP00000020466 | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. | 0.963 |