TIMP1 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

TIMP1

Metalloproteinase inhibitor 1. (359 aa)

Predicted Functional Partners:

MMP9

0.983

MMP1

0.961

MMP14

0.942

CD63

0.916

TIMP2

0.861

MMP8

0.853

MMP13

0.823

MMP15

0.796

MMP7

0.788

MMP2

0.783

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD63	TIMP1	ENSCAFP00000041004	ENSCAFP00000062428	Tetraspanin.	Metalloproteinase inhibitor 1.	0.916
MMP1	MMP13	ENSCAFP00000038708	ENSCAFP00000022174	Matrix metallopeptidase 1.	Matrix metallopeptidase 13.	0.621
MMP1	MMP14	ENSCAFP00000038708	ENSCAFP00000016472	Matrix metallopeptidase 1.	Matrix metallopeptidase 14.	0.492
MMP1	MMP15	ENSCAFP00000038708	ENSCAFP00000012558	Matrix metallopeptidase 1.	Matrix metallopeptidase 15.	0.493
MMP1	MMP2	ENSCAFP00000038708	ENSCAFP00000013872	Matrix metallopeptidase 1.	Matrix metallopeptidase 2.	0.785
MMP1	MMP7	ENSCAFP00000038708	ENSCAFP00000030464	Matrix metallopeptidase 1.	Matrix metallopeptidase 7.	0.742
MMP1	MMP9	ENSCAFP00000038708	ENSCAFP00000035167	Matrix metallopeptidase 1.	Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).	0.945
MMP1	TIMP1	ENSCAFP00000038708	ENSCAFP00000062428	Matrix metallopeptidase 1.	Metalloproteinase inhibitor 1.	0.961
MMP1	TIMP2	ENSCAFP00000038708	ENSCAFP00000035219	Matrix metallopeptidase 1.	Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family.	0.836
MMP13	MMP1	ENSCAFP00000022174	ENSCAFP00000038708	Matrix metallopeptidase 13.	Matrix metallopeptidase 1.	0.621
MMP13	MMP14	ENSCAFP00000022174	ENSCAFP00000016472	Matrix metallopeptidase 13.	Matrix metallopeptidase 14.	0.910
MMP13	MMP15	ENSCAFP00000022174	ENSCAFP00000012558	Matrix metallopeptidase 13.	Matrix metallopeptidase 15.	0.449
MMP13	MMP7	ENSCAFP00000022174	ENSCAFP00000030464	Matrix metallopeptidase 13.	Matrix metallopeptidase 7.	0.765
MMP13	MMP9	ENSCAFP00000022174	ENSCAFP00000035167	Matrix metallopeptidase 13.	Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).	0.599
MMP13	TIMP1	ENSCAFP00000022174	ENSCAFP00000062428	Matrix metallopeptidase 13.	Metalloproteinase inhibitor 1.	0.823
MMP13	TIMP2	ENSCAFP00000022174	ENSCAFP00000035219	Matrix metallopeptidase 13.	Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family.	0.837
MMP14	MMP1	ENSCAFP00000016472	ENSCAFP00000038708	Matrix metallopeptidase 14.	Matrix metallopeptidase 1.	0.492
MMP14	MMP13	ENSCAFP00000016472	ENSCAFP00000022174	Matrix metallopeptidase 14.	Matrix metallopeptidase 13.	0.910
MMP14	MMP15	ENSCAFP00000016472	ENSCAFP00000012558	Matrix metallopeptidase 14.	Matrix metallopeptidase 15.	0.516
MMP14	MMP2	ENSCAFP00000016472	ENSCAFP00000013872	Matrix metallopeptidase 14.	Matrix metallopeptidase 2.	0.897