STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TNFSF10Tumor necrosis factor ligand superfamily member. (296 aa)    
Predicted Functional Partners:
LOC100688321
Uncharacterized protein.
    
 0.982
CASP8
Caspase 8; Belongs to the peptidase C14A family.
   
 0.874
RIPK1
Receptor interacting serine/threonine kinase 1.
   
 0.767
CFLAR
CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family.
   
 
 0.746
TNFRSF11B
Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.
      
 0.666
TNFRSF1A
TNF receptor superfamily member 1A.
   
  
 0.635
TRADD
TNFRSF1A associated via death domain.
   
 
 0.629
TNFRSF25
TNF receptor superfamily member 25.
      
 0.598
PLEKHF1
Pleckstrin homology and FYVE domain containing 1.
   
  
 0.575
TRAF2
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.547
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.