Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TNFSF10Tumor necrosis factor ligand superfamily member. (296 aa)    
Predicted Functional Partners:
LOC100688321
Uncharacterized protein.
    
 0.976
CFLAR
CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family.
   
 
 0.962
CASP8
Caspase 8; Belongs to the peptidase C14A family.
   
 
 0.882
TNFRSF11B
Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.
     
 0.765
RIPK1
Receptor interacting serine/threonine kinase 1.
    
 
 0.692
TNFRSF11A
TNF receptor superfamily member 11a.
     
 0.618
CUL3
Cullin 3; Belongs to the cullin family.
    
   0.573
CASP3
Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.
   
 
 0.542
CASP9
Caspase 9; Belongs to the peptidase C14A family.
   
 
 0.535
TNFRSF1A
TNF receptor superfamily member 1A.
   
  
 0.525
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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