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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DESDesmin; Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-ancho [...] (644 aa)    
Predicted Functional Partners:
PCYT1A
Phosphate cytidylyltransferase 1, choline, alpha.
   
   0.806
DLA-DRA
Ig-like domain-containing protein; Belongs to the MHC class II family.
    
   0.660
GAN
Gigaxonin.
    
 
 0.637
MYBPC1
Myosin binding protein C, slow type.
   
 0.629
MYL1
Myosin light chain 1.
   
 0.617
SPIB
Myosin binding protein C, fast type.
   
 0.615
MYBPC3
Myosin binding protein C, cardiac.
   
 0.602
TNNT3
Troponin T3, fast skeletal type.
   
 
  0.599
F1PSQ5_CANLF
Uncharacterized protein.
   
 
 0.590
MYL3
Myosin light chain 3.
   
 0.587
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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