NLRP1 protein (Canis lupus familiaris) - STRING interaction network

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Score

NLRP1

NLR family pyrin domain containing 1. (1432 aa)

Predicted Functional Partners:

PYCARD

0.994

CASP4

0.991

GSDMD

0.989

BCL2L1

0.970

CARD8

0.969

CASP12

0.962

LOC100688504

0.936

BCL2

0.913

NLRP3

0.910

IL18

0.871

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	BCL2L1	ENSCAFP00000000102	ENSCAFP00000010478	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	BCL2 like 1.	0.995
BCL2	CASP12	ENSCAFP00000000102	ENSCAFP00000042646	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	Caspase-12; Involved in the activation cascade of caspases responsible for apoptosis execution.	0.722
BCL2	CASP4	ENSCAFP00000000102	ENSCAFP00000031566	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.725
BCL2	IL18	ENSCAFP00000000102	ENSCAFP00000038185	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.787
BCL2	NLRP1	ENSCAFP00000000102	ENSCAFP00000022816	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	NLR family pyrin domain containing 1.	0.913
BCL2L1	BCL2	ENSCAFP00000010478	ENSCAFP00000000102	BCL2 like 1.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	0.995
BCL2L1	CASP12	ENSCAFP00000010478	ENSCAFP00000042646	BCL2 like 1.	Caspase-12; Involved in the activation cascade of caspases responsible for apoptosis execution.	0.446
BCL2L1	CASP4	ENSCAFP00000010478	ENSCAFP00000031566	BCL2 like 1.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.463
BCL2L1	NLRP1	ENSCAFP00000010478	ENSCAFP00000022816	BCL2 like 1.	NLR family pyrin domain containing 1.	0.970
CARD8	CASP12	ENSCAFP00000053507	ENSCAFP00000042646	Uncharacterized protein.	Caspase-12; Involved in the activation cascade of caspases responsible for apoptosis execution.	0.907
CARD8	CASP4	ENSCAFP00000053507	ENSCAFP00000031566	Uncharacterized protein.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.941
CARD8	GSDMD	ENSCAFP00000053507	ENSCAFP00000033873	Uncharacterized protein.	Gasdermin D.	0.952
CARD8	IL18	ENSCAFP00000053507	ENSCAFP00000038185	Uncharacterized protein.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.429
CARD8	NLRP1	ENSCAFP00000053507	ENSCAFP00000022816	Uncharacterized protein.	NLR family pyrin domain containing 1.	0.969
CARD8	NLRP3	ENSCAFP00000053507	ENSCAFP00000015730	Uncharacterized protein.	NLR family pyrin domain containing 3.	0.961
CARD8	PYCARD	ENSCAFP00000053507	ENSCAFP00000024803	Uncharacterized protein.	PYD and CARD domain containing.	0.940
CASP12	BCL2	ENSCAFP00000042646	ENSCAFP00000000102	Caspase-12; Involved in the activation cascade of caspases responsible for apoptosis execution.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).	0.722
CASP12	BCL2L1	ENSCAFP00000042646	ENSCAFP00000010478	Caspase-12; Involved in the activation cascade of caspases responsible for apoptosis execution.	BCL2 like 1.	0.446
CASP12	CARD8	ENSCAFP00000042646	ENSCAFP00000053507	Caspase-12; Involved in the activation cascade of caspases responsible for apoptosis execution.	Uncharacterized protein.	0.907
CASP12	CASP4	ENSCAFP00000042646	ENSCAFP00000031566	Caspase-12; Involved in the activation cascade of caspases responsible for apoptosis execution.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.991