HDAC6 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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gene co-occurrence

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Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CFTR	HDAC6	ENSCAFP00000005112	ENSCAFP00000049288	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Histone deacetylase 6.	0.898
CFTR	MAPT	ENSCAFP00000005112	ENSCAFP00000046670	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Microtubule-associated protein.	0.424
CFTR	PRKN	ENSCAFP00000005112	ENSCAFP00000050441	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.525
CFTR	SQSTM1	ENSCAFP00000005112	ENSCAFP00000065910	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Sequestosome 1.	0.579
CFTR	VCP	ENSCAFP00000005112	ENSCAFP00000002927	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Valosin containing protein; Belongs to the AAA ATPase family.	0.939
CTTN	EGFR	ENSCAFP00000050998	ENSCAFP00000005164	Cortactin.	Receptor protein-tyrosine kinase.	0.853
CTTN	HDAC6	ENSCAFP00000050998	ENSCAFP00000049288	Cortactin.	Histone deacetylase 6.	0.956
CTTN	MAPT	ENSCAFP00000050998	ENSCAFP00000046670	Cortactin.	Microtubule-associated protein.	0.508
EGFR	CTTN	ENSCAFP00000005164	ENSCAFP00000050998	Receptor protein-tyrosine kinase.	Cortactin.	0.853
EGFR	HDAC6	ENSCAFP00000005164	ENSCAFP00000049288	Receptor protein-tyrosine kinase.	Histone deacetylase 6.	0.871
EGFR	MAPT	ENSCAFP00000005164	ENSCAFP00000046670	Receptor protein-tyrosine kinase.	Microtubule-associated protein.	0.799
EGFR	PRKN	ENSCAFP00000005164	ENSCAFP00000050441	Receptor protein-tyrosine kinase.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.412
EP300	HDAC6	ENSCAFP00000001585	ENSCAFP00000049288	E1A binding protein p300.	Histone deacetylase 6.	0.889
EP300	MAPT	ENSCAFP00000001585	ENSCAFP00000046670	E1A binding protein p300.	Microtubule-associated protein.	0.791
EP300	SIRT2	ENSCAFP00000001585	ENSCAFP00000054577	E1A binding protein p300.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.880
G3BP1	HDAC6	ENSCAFP00000054602	ENSCAFP00000049288	G3BP stress granule assembly factor 1.	Histone deacetylase 6.	0.879
G3BP1	MAPT	ENSCAFP00000054602	ENSCAFP00000046670	G3BP stress granule assembly factor 1.	Microtubule-associated protein.	0.605
G3BP1	SQSTM1	ENSCAFP00000054602	ENSCAFP00000065910	G3BP stress granule assembly factor 1.	Sequestosome 1.	0.742
G3BP1	VCP	ENSCAFP00000054602	ENSCAFP00000002927	G3BP stress granule assembly factor 1.	Valosin containing protein; Belongs to the AAA ATPase family.	0.798
HDAC6	CFTR	ENSCAFP00000049288	ENSCAFP00000005112	Histone deacetylase 6.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	0.898