ESR2 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Knowledge-based Evidence

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

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Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ESR1	ESR2	ENSCAFP00000000624	ENSCAFP00000023305	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Estrogen receptor 2.	0.999
ESR1	MAPK1	ENSCAFP00000000624	ENSCAFP00000030998	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.950
ESR1	MED1	ENSCAFP00000000624	ENSCAFP00000024203	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.995
ESR1	NCOA1	ENSCAFP00000000624	ENSCAFP00000006049	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.998
ESR1	NCOA2	ENSCAFP00000000624	ENSCAFP00000065782	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator 2.	0.996
ESR1	NCOA3	ENSCAFP00000000624	ENSCAFP00000015958	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.996
ESR1	NCOR1	ENSCAFP00000000624	ENSCAFP00000053648	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor corepressor 1.	0.996
ESR1	PRKACB	ENSCAFP00000000624	ENSCAFP00000030135	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.933
ESR1	SP1	ENSCAFP00000000624	ENSCAFP00000010330	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Sp1 transcription factor.	0.996
ESR1	SRC	ENSCAFP00000000624	ENSCAFP00000044994	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Tyrosine-protein kinase.	0.992
ESR2	ESR1	ENSCAFP00000023305	ENSCAFP00000000624	Estrogen receptor 2.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.999
ESR2	MAPK1	ENSCAFP00000023305	ENSCAFP00000030998	Estrogen receptor 2.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.937
ESR2	MED1	ENSCAFP00000023305	ENSCAFP00000024203	Estrogen receptor 2.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.987
ESR2	NCOA1	ENSCAFP00000023305	ENSCAFP00000006049	Estrogen receptor 2.	Nuclear receptor coactivator.	0.995
ESR2	NCOA2	ENSCAFP00000023305	ENSCAFP00000065782	Estrogen receptor 2.	Nuclear receptor coactivator 2.	0.982
ESR2	NCOA3	ENSCAFP00000023305	ENSCAFP00000015958	Estrogen receptor 2.	Nuclear receptor coactivator.	0.994
ESR2	NCOR1	ENSCAFP00000023305	ENSCAFP00000053648	Estrogen receptor 2.	Nuclear receptor corepressor 1.	0.970
ESR2	PRKACB	ENSCAFP00000023305	ENSCAFP00000030135	Estrogen receptor 2.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.916
ESR2	SP1	ENSCAFP00000023305	ENSCAFP00000010330	Estrogen receptor 2.	Sp1 transcription factor.	0.964
ESR2	SRC	ENSCAFP00000023305	ENSCAFP00000044994	Estrogen receptor 2.	Tyrosine-protein kinase.	0.980