MTOR protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MTOR

Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2647 aa)

Predicted Functional Partners:

RPTOR

0.999

RICTOR

0.999

MLST8

0.999

EIF4EBP1

0.998

ULK1

0.998

RRAGC

0.997

TTI1

0.996

RHEB

0.996

MAPKAP1

0.996

AKT1S1

0.993

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1S1	EIF4EBP1	ENSCAFP00000005180	ENSCAFP00000009244	AKT1 substrate 1.	Eukaryotic translation initiation factor 4E binding protein 1.	0.969
AKT1S1	MAPKAP1	ENSCAFP00000005180	ENSCAFP00000057077	AKT1 substrate 1.	MAPK associated protein 1.	0.902
AKT1S1	MLST8	ENSCAFP00000005180	ENSCAFP00000030885	AKT1 substrate 1.	MTOR associated protein, LST8 homolog.	0.988
AKT1S1	MTOR	ENSCAFP00000005180	ENSCAFP00000024527	AKT1 substrate 1.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.993
AKT1S1	RHEB	ENSCAFP00000005180	ENSCAFP00000050252	AKT1 substrate 1.	Ras homolog, mTORC1 binding.	0.928
AKT1S1	RICTOR	ENSCAFP00000005180	ENSCAFP00000027508	AKT1 substrate 1.	RPTOR independent companion of MTOR complex 2.	0.601
AKT1S1	RPTOR	ENSCAFP00000005180	ENSCAFP00000008518	AKT1 substrate 1.	Regulatory associated protein of MTOR complex 1.	0.997
AKT1S1	RRAGC	ENSCAFP00000005180	ENSCAFP00000004762	AKT1 substrate 1.	Ras related GTP binding C.	0.951
AKT1S1	TTI1	ENSCAFP00000005180	ENSCAFP00000045584	AKT1 substrate 1.	TELO2 interacting protein 1.	0.608
AKT1S1	ULK1	ENSCAFP00000005180	ENSCAFP00000009679	AKT1 substrate 1.	Unc-51 like autophagy activating kinase 1.	0.948
EIF4EBP1	AKT1S1	ENSCAFP00000009244	ENSCAFP00000005180	Eukaryotic translation initiation factor 4E binding protein 1.	AKT1 substrate 1.	0.969
EIF4EBP1	MAPKAP1	ENSCAFP00000009244	ENSCAFP00000057077	Eukaryotic translation initiation factor 4E binding protein 1.	MAPK associated protein 1.	0.573
EIF4EBP1	MLST8	ENSCAFP00000009244	ENSCAFP00000030885	Eukaryotic translation initiation factor 4E binding protein 1.	MTOR associated protein, LST8 homolog.	0.993
EIF4EBP1	MTOR	ENSCAFP00000009244	ENSCAFP00000024527	Eukaryotic translation initiation factor 4E binding protein 1.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.998
EIF4EBP1	RHEB	ENSCAFP00000009244	ENSCAFP00000050252	Eukaryotic translation initiation factor 4E binding protein 1.	Ras homolog, mTORC1 binding.	0.829
EIF4EBP1	RICTOR	ENSCAFP00000009244	ENSCAFP00000027508	Eukaryotic translation initiation factor 4E binding protein 1.	RPTOR independent companion of MTOR complex 2.	0.410
EIF4EBP1	RPTOR	ENSCAFP00000009244	ENSCAFP00000008518	Eukaryotic translation initiation factor 4E binding protein 1.	Regulatory associated protein of MTOR complex 1.	0.997
EIF4EBP1	RRAGC	ENSCAFP00000009244	ENSCAFP00000004762	Eukaryotic translation initiation factor 4E binding protein 1.	Ras related GTP binding C.	0.833
MAPKAP1	AKT1S1	ENSCAFP00000057077	ENSCAFP00000005180	MAPK associated protein 1.	AKT1 substrate 1.	0.902
MAPKAP1	EIF4EBP1	ENSCAFP00000057077	ENSCAFP00000009244	MAPK associated protein 1.	Eukaryotic translation initiation factor 4E binding protein 1.	0.573