ANXA2 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ANXA2

Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family. (362 aa)

Predicted Functional Partners:

S100A10

0.994

ANXA1

0.882

S100A11

0.861

S100A5

0.855

ENSCAFP00000038290

0.848

J9P5V4_CANLF

0.848

ENSCAFP00000055586

0.848

PLAT

0.841

AHNAK-2

0.781

AHNAK

0.777

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHNAK	AHNAK-2	ENSCAFP00000042302	ENSCAFP00000063046	AHNAK nucleoprotein.	PDZ domain-containing protein.	0.833
AHNAK	ANXA1	ENSCAFP00000042302	ENSCAFP00000002591	AHNAK nucleoprotein.	Annexin.	0.548
AHNAK	ANXA2	ENSCAFP00000042302	ENSCAFP00000049994	AHNAK nucleoprotein.	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family.	0.777
AHNAK	ENSCAFP00000038290	ENSCAFP00000042302	ENSCAFP00000038290	AHNAK nucleoprotein.	annotation not available	0.758
AHNAK	ENSCAFP00000055586	ENSCAFP00000042302	ENSCAFP00000055586	AHNAK nucleoprotein.	S_100 domain-containing protein; Belongs to the S-100 family.	0.758
AHNAK	J9P5V4_CANLF	ENSCAFP00000042302	ENSCAFP00000041034	AHNAK nucleoprotein.	S_100 domain-containing protein; Belongs to the S-100 family.	0.758
AHNAK	S100A10	ENSCAFP00000042302	ENSCAFP00000019017	AHNAK nucleoprotein.	S_100 domain-containing protein; Belongs to the S-100 family.	0.758
AHNAK-2	AHNAK	ENSCAFP00000063046	ENSCAFP00000042302	PDZ domain-containing protein.	AHNAK nucleoprotein.	0.833
AHNAK-2	ANXA1	ENSCAFP00000063046	ENSCAFP00000002591	PDZ domain-containing protein.	Annexin.	0.548
AHNAK-2	ANXA2	ENSCAFP00000063046	ENSCAFP00000049994	PDZ domain-containing protein.	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family.	0.781
AHNAK-2	ENSCAFP00000038290	ENSCAFP00000063046	ENSCAFP00000038290	PDZ domain-containing protein.	annotation not available	0.758
AHNAK-2	ENSCAFP00000055586	ENSCAFP00000063046	ENSCAFP00000055586	PDZ domain-containing protein.	S_100 domain-containing protein; Belongs to the S-100 family.	0.758
AHNAK-2	J9P5V4_CANLF	ENSCAFP00000063046	ENSCAFP00000041034	PDZ domain-containing protein.	S_100 domain-containing protein; Belongs to the S-100 family.	0.758
AHNAK-2	S100A10	ENSCAFP00000063046	ENSCAFP00000019017	PDZ domain-containing protein.	S_100 domain-containing protein; Belongs to the S-100 family.	0.758
ANXA1	AHNAK	ENSCAFP00000002591	ENSCAFP00000042302	Annexin.	AHNAK nucleoprotein.	0.548
ANXA1	AHNAK-2	ENSCAFP00000002591	ENSCAFP00000063046	Annexin.	PDZ domain-containing protein.	0.548
ANXA1	ANXA2	ENSCAFP00000002591	ENSCAFP00000049994	Annexin.	Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family.	0.882
ANXA1	ENSCAFP00000038290	ENSCAFP00000002591	ENSCAFP00000038290	Annexin.	annotation not available	0.854
ANXA1	ENSCAFP00000055586	ENSCAFP00000002591	ENSCAFP00000055586	Annexin.	S_100 domain-containing protein; Belongs to the S-100 family.	0.854
ANXA1	J9P5V4_CANLF	ENSCAFP00000002591	ENSCAFP00000041034	Annexin.	S_100 domain-containing protein; Belongs to the S-100 family.	0.854

page 1 of 4

Server load: low (18%) [HD]

Permalink

Network

Fusion

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

© STRING Consortium 2026

Credits

Access

Info

About