STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOB1Transducer of ERBB2, 1. (492 aa)    
Predicted Functional Partners:
CNOT7
CCR4-NOT transcription complex subunit 7.
   
 
 0.721
ERBB2
Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]
      
 0.636
CNOT8
CCR4-NOT transcription complex subunit 8.
    
 
 0.592
AFG3L2
AFG3 like matrix AAA peptidase subunit 2.
   
  
 0.573
FGF21
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
   
  
 0.556
TRIM58
Tripartite motif containing 58.
      
 0.527
TASP1
Taspase 1.
      
 0.516
DNAH5
Dynein axonemal heavy chain 5.
      
 0.513
DNAH8
Dynein axonemal heavy chain 8.
      
 0.513
SNAPC1
Small nuclear RNA activating complex polypeptide 1.
   
  
 0.491
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.