node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCL3 | CCL4 | ENSCAFP00000063840 | ENSCAFP00000045688 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | 0.911 |
CCL3 | CCR1 | ENSCAFP00000063840 | ENSCAFP00000054662 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | 0.991 |
CCL3 | CCR2 | ENSCAFP00000063840 | ENSCAFP00000020334 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. | C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. | 0.943 |
CCL3 | CCR3 | ENSCAFP00000063840 | ENSCAFP00000020344 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. | C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. | 0.937 |
CCL3 | CCR5 | ENSCAFP00000063840 | ENSCAFP00000020323 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | 0.999 |
CCL3 | CXCL10 | ENSCAFP00000063840 | ENSCAFP00000032015 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | 0.904 |
CCL3 | CXCL13 | ENSCAFP00000063840 | ENSCAFP00000034611 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. | C-X-C motif chemokine. | 0.911 |
CCL3 | CXCR3 | ENSCAFP00000063840 | ENSCAFP00000025254 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. | C-X-C chemokine receptor type 3; Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity). | 0.906 |
CCL3 | IL10 | ENSCAFP00000063840 | ENSCAFP00000016812 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.890 |
CCL3 | LOC480601 | ENSCAFP00000063840 | ENSCAFP00000040162 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. | SCY domain-containing protein. | 0.903 |
CCL4 | CCL3 | ENSCAFP00000045688 | ENSCAFP00000063840 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. | 0.911 |
CCL4 | CCR1 | ENSCAFP00000045688 | ENSCAFP00000054662 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | 0.949 |
CCL4 | CCR2 | ENSCAFP00000045688 | ENSCAFP00000020334 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. | 0.937 |
CCL4 | CCR3 | ENSCAFP00000045688 | ENSCAFP00000020344 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. | 0.932 |
CCL4 | CCR5 | ENSCAFP00000045688 | ENSCAFP00000020323 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | 0.998 |
CCL4 | CXCL10 | ENSCAFP00000045688 | ENSCAFP00000032015 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | 0.946 |
CCL4 | CXCL13 | ENSCAFP00000045688 | ENSCAFP00000034611 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | C-X-C motif chemokine. | 0.991 |
CCL4 | CXCR3 | ENSCAFP00000045688 | ENSCAFP00000025254 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | C-X-C chemokine receptor type 3; Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity). | 0.934 |
CCL4 | IL10 | ENSCAFP00000045688 | ENSCAFP00000016812 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.774 |
CCR1 | CCL3 | ENSCAFP00000054662 | ENSCAFP00000063840 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5 (By similarity); Belongs to the intercrine beta (chemokine CC) family. | 0.991 |