node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CTNNB1 | PTEN | ENSCAFP00000007783 | ENSCAFP00000045099 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] | 0.803 |
CTNNB1 | RHOA | ENSCAFP00000007783 | ENSCAFP00000030438 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.648 |
CTNNB1 | ROCK1 | ENSCAFP00000007783 | ENSCAFP00000050426 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.953 |
CTNNB1 | ROCK2 | ENSCAFP00000007783 | ENSCAFP00000066507 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.936 |
LIMK1 | RHOA | ENSCAFP00000018366 | ENSCAFP00000030438 | LIM domain kinase 1. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.446 |
LIMK1 | ROCK1 | ENSCAFP00000018366 | ENSCAFP00000050426 | LIM domain kinase 1. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.933 |
LIMK1 | ROCK2 | ENSCAFP00000018366 | ENSCAFP00000066507 | LIM domain kinase 1. | Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.929 |
MYL2 | PPP1R12A | ENSCAFP00000066121 | ENSCAFP00000056860 | Myosin light chain 2. | Protein phosphatase 1 regulatory subunit. | 0.698 |
MYL2 | PPP1R12C | ENSCAFP00000066121 | ENSCAFP00000003816 | Myosin light chain 2. | Protein phosphatase 1 regulatory subunit. | 0.784 |
MYL2 | ROCK1 | ENSCAFP00000066121 | ENSCAFP00000050426 | Myosin light chain 2. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.952 |
MYL2 | ROCK2 | ENSCAFP00000066121 | ENSCAFP00000066507 | Myosin light chain 2. | Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.945 |
PPP1R12A | MYL2 | ENSCAFP00000056860 | ENSCAFP00000066121 | Protein phosphatase 1 regulatory subunit. | Myosin light chain 2. | 0.698 |
PPP1R12A | PPP1R12C | ENSCAFP00000056860 | ENSCAFP00000003816 | Protein phosphatase 1 regulatory subunit. | Protein phosphatase 1 regulatory subunit. | 0.921 |
PPP1R12A | ROCK1 | ENSCAFP00000056860 | ENSCAFP00000050426 | Protein phosphatase 1 regulatory subunit. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.949 |
PPP1R12A | ROCK2 | ENSCAFP00000056860 | ENSCAFP00000066507 | Protein phosphatase 1 regulatory subunit. | Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.933 |
PPP1R12C | MYL2 | ENSCAFP00000003816 | ENSCAFP00000066121 | Protein phosphatase 1 regulatory subunit. | Myosin light chain 2. | 0.784 |
PPP1R12C | PPP1R12A | ENSCAFP00000003816 | ENSCAFP00000056860 | Protein phosphatase 1 regulatory subunit. | Protein phosphatase 1 regulatory subunit. | 0.921 |
PPP1R12C | ROCK1 | ENSCAFP00000003816 | ENSCAFP00000050426 | Protein phosphatase 1 regulatory subunit. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.934 |
PPP1R12C | ROCK2 | ENSCAFP00000003816 | ENSCAFP00000066507 | Protein phosphatase 1 regulatory subunit. | Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. | 0.925 |
PTEN | CTNNB1 | ENSCAFP00000045099 | ENSCAFP00000007783 | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | 0.803 |