AKT1 protein (Canis lupus familiaris) - STRING interaction network

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Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	BAD	ENSCAFP00000027133	ENSCAFP00000034035	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 associated agonist of cell death.	0.934
AKT1	BRCA1	ENSCAFP00000027133	ENSCAFP00000048759	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.938
AKT1	CDKN1A	ENSCAFP00000027133	ENSCAFP00000050190	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1A.	0.934
AKT1	FOXO1	ENSCAFP00000027133	ENSCAFP00000008944	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O1.	0.937
AKT1	ILK	ENSCAFP00000027133	ENSCAFP00000033861	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Integrin linked kinase.	0.934
AKT1	MTOR	ENSCAFP00000027133	ENSCAFP00000024527	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.970
AKT1	NOS3	ENSCAFP00000027133	ENSCAFP00000061234	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity); Belongs to the NOS family.	0.944
AKT1	PDPK1	ENSCAFP00000027133	ENSCAFP00000053509	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	3-phosphoinositide dependent protein kinase 1.	0.946
AKT1	PIK3CA	ENSCAFP00000027133	ENSCAFP00000048355	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.965
AKT1	PIK3R1	ENSCAFP00000027133	ENSCAFP00000011322	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.948
BAD	AKT1	ENSCAFP00000034035	ENSCAFP00000027133	BCL2 associated agonist of cell death.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.934
BRCA1	AKT1	ENSCAFP00000048759	ENSCAFP00000027133	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.938
BRCA1	CDKN1A	ENSCAFP00000048759	ENSCAFP00000050190	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Cyclin dependent kinase inhibitor 1A.	0.534
BRCA1	MTOR	ENSCAFP00000048759	ENSCAFP00000024527	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.491
BRCA1	PIK3CA	ENSCAFP00000048759	ENSCAFP00000048355	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.622
CDKN1A	AKT1	ENSCAFP00000050190	ENSCAFP00000027133	Cyclin dependent kinase inhibitor 1A.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.934
CDKN1A	BRCA1	ENSCAFP00000050190	ENSCAFP00000048759	Cyclin dependent kinase inhibitor 1A.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.534
CDKN1A	FOXO1	ENSCAFP00000050190	ENSCAFP00000008944	Cyclin dependent kinase inhibitor 1A.	Forkhead box O1.	0.585
CDKN1A	MTOR	ENSCAFP00000050190	ENSCAFP00000024527	Cyclin dependent kinase inhibitor 1A.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.403
FOXO1	AKT1	ENSCAFP00000008944	ENSCAFP00000027133	Forkhead box O1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.937