node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTS13 | F7 | ENSCAFP00000029268 | ENSCAFP00000055494 | ADAM metallopeptidase with thrombospondin type 1 motif 13. | Coagulation factor X. | 0.556 |
ADAMTS13 | F8 | ENSCAFP00000029268 | ENSCAFP00000029035 | ADAM metallopeptidase with thrombospondin type 1 motif 13. | Coagulation factor VIII; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. | 0.596 |
ADAMTS13 | SSPO | ENSCAFP00000029268 | ENSCAFP00000040196 | ADAM metallopeptidase with thrombospondin type 1 motif 13. | SCO-spondin. | 0.533 |
ADAMTS13 | VWF | ENSCAFP00000029268 | ENSCAFP00000053390 | ADAM metallopeptidase with thrombospondin type 1 motif 13. | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). | 0.928 |
ATP7B | F8 | ENSCAFP00000006351 | ENSCAFP00000029035 | ATPase copper transporting beta. | Coagulation factor VIII; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. | 0.465 |
F2 | F7 | ENSCAFP00000037638 | ENSCAFP00000055494 | Coagulation factor II, thrombin; Belongs to the peptidase S1 family. | Coagulation factor X. | 0.978 |
F2 | F8 | ENSCAFP00000037638 | ENSCAFP00000029035 | Coagulation factor II, thrombin; Belongs to the peptidase S1 family. | Coagulation factor VIII; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. | 0.711 |
F2 | F9 | ENSCAFP00000037638 | ENSCAFP00000028031 | Coagulation factor II, thrombin; Belongs to the peptidase S1 family. | Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa; Belongs to the peptidase S1 family. | 0.687 |
F2 | FN1 | ENSCAFP00000037638 | ENSCAFP00000066679 | Coagulation factor II, thrombin; Belongs to the peptidase S1 family. | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | 0.505 |
F2 | SERPINC1 | ENSCAFP00000037638 | ENSCAFP00000021382 | Coagulation factor II, thrombin; Belongs to the peptidase S1 family. | Serpin family C member 1; Belongs to the serpin family. | 0.998 |
F2 | VWF | ENSCAFP00000037638 | ENSCAFP00000053390 | Coagulation factor II, thrombin; Belongs to the peptidase S1 family. | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). | 0.637 |
F7 | ADAMTS13 | ENSCAFP00000055494 | ENSCAFP00000029268 | Coagulation factor X. | ADAM metallopeptidase with thrombospondin type 1 motif 13. | 0.556 |
F7 | F2 | ENSCAFP00000055494 | ENSCAFP00000037638 | Coagulation factor X. | Coagulation factor II, thrombin; Belongs to the peptidase S1 family. | 0.978 |
F7 | F8 | ENSCAFP00000055494 | ENSCAFP00000029035 | Coagulation factor X. | Coagulation factor VIII; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. | 0.738 |
F7 | SERPINC1 | ENSCAFP00000055494 | ENSCAFP00000021382 | Coagulation factor X. | Serpin family C member 1; Belongs to the serpin family. | 0.959 |
F8 | ADAMTS13 | ENSCAFP00000029035 | ENSCAFP00000029268 | Coagulation factor VIII; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. | ADAM metallopeptidase with thrombospondin type 1 motif 13. | 0.596 |
F8 | ATP7B | ENSCAFP00000029035 | ENSCAFP00000006351 | Coagulation factor VIII; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. | ATPase copper transporting beta. | 0.465 |
F8 | F2 | ENSCAFP00000029035 | ENSCAFP00000037638 | Coagulation factor VIII; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. | Coagulation factor II, thrombin; Belongs to the peptidase S1 family. | 0.711 |
F8 | F7 | ENSCAFP00000029035 | ENSCAFP00000055494 | Coagulation factor VIII; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. | Coagulation factor X. | 0.738 |
F8 | F9 | ENSCAFP00000029035 | ENSCAFP00000028031 | Coagulation factor VIII; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. | Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa; Belongs to the peptidase S1 family. | 0.801 |