node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NCOA1 | NCOA2 | ENSCAFP00000006049 | ENSCAFP00000065782 | Nuclear receptor coactivator. | Nuclear receptor coactivator 2. | 0.983 |
NCOA1 | NR1H2 | ENSCAFP00000006049 | ENSCAFP00000004950 | Nuclear receptor coactivator. | Nuclear receptor subfamily 1 group H member 2. | 0.858 |
NCOA1 | NR1H3 | ENSCAFP00000006049 | ENSCAFP00000012970 | Nuclear receptor coactivator. | Nuclear receptor subfamily 1 group H member 3. | 0.858 |
NCOA1 | PPARA | ENSCAFP00000006049 | ENSCAFP00000054067 | Nuclear receptor coactivator. | Peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and [...] | 0.973 |
NCOA1 | PPARD | ENSCAFP00000006049 | ENSCAFP00000052536 | Nuclear receptor coactivator. | Peroxisome proliferator-activated receptor delta; Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma- linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity). | 0.604 |
NCOA1 | PPARG | ENSCAFP00000006049 | ENSCAFP00000007423 | Nuclear receptor coactivator. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.959 |
NCOA1 | RARA | ENSCAFP00000006049 | ENSCAFP00000010481 | Nuclear receptor coactivator. | Retinoic acid receptor alpha; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcri [...] | 0.571 |
NCOA1 | RXRA | ENSCAFP00000006049 | ENSCAFP00000058322 | Nuclear receptor coactivator. | Retinoid X receptor alpha. | 0.962 |
NCOA1 | VDR | ENSCAFP00000006049 | ENSCAFP00000013418 | Nuclear receptor coactivator. | Vitamin D receptor. | 0.709 |
NCOA2 | NCOA1 | ENSCAFP00000065782 | ENSCAFP00000006049 | Nuclear receptor coactivator 2. | Nuclear receptor coactivator. | 0.983 |
NCOA2 | NR1H2 | ENSCAFP00000065782 | ENSCAFP00000004950 | Nuclear receptor coactivator 2. | Nuclear receptor subfamily 1 group H member 2. | 0.840 |
NCOA2 | NR1H3 | ENSCAFP00000065782 | ENSCAFP00000012970 | Nuclear receptor coactivator 2. | Nuclear receptor subfamily 1 group H member 3. | 0.875 |
NCOA2 | PPARA | ENSCAFP00000065782 | ENSCAFP00000054067 | Nuclear receptor coactivator 2. | Peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and [...] | 0.816 |
NCOA2 | PPARG | ENSCAFP00000065782 | ENSCAFP00000007423 | Nuclear receptor coactivator 2. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.912 |
NCOA2 | RARA | ENSCAFP00000065782 | ENSCAFP00000010481 | Nuclear receptor coactivator 2. | Retinoic acid receptor alpha; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcri [...] | 0.569 |
NCOA2 | RXRA | ENSCAFP00000065782 | ENSCAFP00000058322 | Nuclear receptor coactivator 2. | Retinoid X receptor alpha. | 0.950 |
NCOA2 | VDR | ENSCAFP00000065782 | ENSCAFP00000013418 | Nuclear receptor coactivator 2. | Vitamin D receptor. | 0.754 |
NR1H2 | NCOA1 | ENSCAFP00000004950 | ENSCAFP00000006049 | Nuclear receptor subfamily 1 group H member 2. | Nuclear receptor coactivator. | 0.858 |
NR1H2 | NCOA2 | ENSCAFP00000004950 | ENSCAFP00000065782 | Nuclear receptor subfamily 1 group H member 2. | Nuclear receptor coactivator 2. | 0.840 |
NR1H2 | NR1H3 | ENSCAFP00000004950 | ENSCAFP00000012970 | Nuclear receptor subfamily 1 group H member 2. | Nuclear receptor subfamily 1 group H member 3. | 0.902 |