Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
HSF4Heat shock factor protein 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). (492 aa)    
Predicted Functional Partners:
HSF2
Heat shock transcription factor 2.
    
 
 0.836
HSPBP1
HSPA (Hsp70) binding protein 1.
   
 
 0.737
HSPA4
Heat shock 70 kDa protein 4.
   
 
 0.725
HSF1
Heat shock transcription factor 1.
    
   0.692
STUB1
STIP1 homology and U-box containing protein 1.
   
 
 0.614
BFSP1
Beaded filament structural protein 1; Belongs to the intermediate filament family.
      
 0.580
HSPB1
Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins.
   
 
 0.580
LIM2
Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family.
      
 0.566
NOL3
Nucleolar protein 3.
 
 
  
 0.539
IL23A
Interleukin 23 subunit alpha.
      
 0.537
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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