| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BCL2L1 | DAXX | ENSCAFP00000010478 | ENSCAFP00000048726 | BCL2 like 1. | Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...] | 0.613 |
| BCL2L1 | PARK7 | ENSCAFP00000010478 | ENSCAFP00000062561 | BCL2 like 1. | Parkinsonism associated deglycase. | 0.902 |
| BCL2L1 | PINK1 | ENSCAFP00000010478 | ENSCAFP00000057576 | BCL2 like 1. | PTEN induced kinase 1. | 0.962 |
| BCL2L1 | PRKN | ENSCAFP00000010478 | ENSCAFP00000050441 | BCL2 like 1. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. | 0.866 |
| BCL2L1 | TP53 | ENSCAFP00000010478 | ENSCAFP00000064590 | BCL2 like 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.991 |
| DAXX | BCL2L1 | ENSCAFP00000048726 | ENSCAFP00000010478 | Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...] | BCL2 like 1. | 0.613 |
| DAXX | MAP3K5 | ENSCAFP00000048726 | ENSCAFP00000000362 | Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...] | Mitogen-activated protein kinase kinase kinase 5. | 0.995 |
| DAXX | PARK7 | ENSCAFP00000048726 | ENSCAFP00000062561 | Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...] | Parkinsonism associated deglycase. | 0.932 |
| DAXX | TP53 | ENSCAFP00000048726 | ENSCAFP00000064590 | Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.994 |
| MAP3K5 | DAXX | ENSCAFP00000000362 | ENSCAFP00000048726 | Mitogen-activated protein kinase kinase kinase 5. | Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...] | 0.995 |
| MAP3K5 | PARK7 | ENSCAFP00000000362 | ENSCAFP00000062561 | Mitogen-activated protein kinase kinase kinase 5. | Parkinsonism associated deglycase. | 0.964 |
| NFE2L2 | PARK7 | ENSCAFP00000033899 | ENSCAFP00000062561 | Nuclear factor, erythroid 2 like 2. | Parkinsonism associated deglycase. | 0.926 |
| NFE2L2 | PINK1 | ENSCAFP00000033899 | ENSCAFP00000057576 | Nuclear factor, erythroid 2 like 2. | PTEN induced kinase 1. | 0.483 |
| NFE2L2 | SOD1 | ENSCAFP00000033899 | ENSCAFP00000013012 | Nuclear factor, erythroid 2 like 2. | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. | 0.564 |
| NFE2L2 | TP53 | ENSCAFP00000033899 | ENSCAFP00000064590 | Nuclear factor, erythroid 2 like 2. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.629 |
| PARK7 | BCL2L1 | ENSCAFP00000062561 | ENSCAFP00000010478 | Parkinsonism associated deglycase. | BCL2 like 1. | 0.902 |
| PARK7 | DAXX | ENSCAFP00000062561 | ENSCAFP00000048726 | Parkinsonism associated deglycase. | Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...] | 0.932 |
| PARK7 | MAP3K5 | ENSCAFP00000062561 | ENSCAFP00000000362 | Parkinsonism associated deglycase. | Mitogen-activated protein kinase kinase kinase 5. | 0.964 |
| PARK7 | NFE2L2 | ENSCAFP00000062561 | ENSCAFP00000033899 | Parkinsonism associated deglycase. | Nuclear factor, erythroid 2 like 2. | 0.926 |
| PARK7 | PINK1 | ENSCAFP00000062561 | ENSCAFP00000057576 | Parkinsonism associated deglycase. | PTEN induced kinase 1. | 0.928 |
