node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATM | HUS1 | ENSCAFP00000035996 | ENSCAFP00000066175 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | HUS1 checkpoint clamp component. | 0.830 |
ATM | LOC606761 | ENSCAFP00000035996 | ENSCAFP00000035144 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | zf-4CXXC_R1 domain-containing protein. | 0.644 |
ATM | RAD1 | ENSCAFP00000035996 | ENSCAFP00000027743 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | RAD1 checkpoint DNA exonuclease. | 0.858 |
ATM | RAD17 | ENSCAFP00000035996 | ENSCAFP00000011526 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | RAD17 checkpoint clamp loader component. | 0.911 |
ATM | RFC2 | ENSCAFP00000035996 | ENSCAFP00000050887 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Replication factor C subunit 2. | 0.726 |
ATM | RFC3 | ENSCAFP00000035996 | ENSCAFP00000009422 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Replication factor C subunit 3. | 0.716 |
ATM | RFC4 | ENSCAFP00000035996 | ENSCAFP00000020162 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Replication factor C subunit 4. | 0.734 |
ATM | RFC5 | ENSCAFP00000035996 | ENSCAFP00000014551 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Replication factor C subunit 5. | 0.714 |
ATM | SLF1 | ENSCAFP00000035996 | ENSCAFP00000011873 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | SMC5-SMC6 complex localization factor 1. | 0.567 |
ATM | TOPBP1 | ENSCAFP00000035996 | ENSCAFP00000009662 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | DNA topoisomerase II binding protein 1. | 0.935 |
HUS1 | ATM | ENSCAFP00000066175 | ENSCAFP00000035996 | HUS1 checkpoint clamp component. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.830 |
HUS1 | LOC606761 | ENSCAFP00000066175 | ENSCAFP00000035144 | HUS1 checkpoint clamp component. | zf-4CXXC_R1 domain-containing protein. | 0.793 |
HUS1 | RAD1 | ENSCAFP00000066175 | ENSCAFP00000027743 | HUS1 checkpoint clamp component. | RAD1 checkpoint DNA exonuclease. | 0.999 |
HUS1 | RAD17 | ENSCAFP00000066175 | ENSCAFP00000011526 | HUS1 checkpoint clamp component. | RAD17 checkpoint clamp loader component. | 0.997 |
HUS1 | RFC2 | ENSCAFP00000066175 | ENSCAFP00000050887 | HUS1 checkpoint clamp component. | Replication factor C subunit 2. | 0.961 |
HUS1 | RFC3 | ENSCAFP00000066175 | ENSCAFP00000009422 | HUS1 checkpoint clamp component. | Replication factor C subunit 3. | 0.961 |
HUS1 | RFC4 | ENSCAFP00000066175 | ENSCAFP00000020162 | HUS1 checkpoint clamp component. | Replication factor C subunit 4. | 0.973 |
HUS1 | RFC5 | ENSCAFP00000066175 | ENSCAFP00000014551 | HUS1 checkpoint clamp component. | Replication factor C subunit 5. | 0.954 |
HUS1 | SLF1 | ENSCAFP00000066175 | ENSCAFP00000011873 | HUS1 checkpoint clamp component. | SMC5-SMC6 complex localization factor 1. | 0.597 |
HUS1 | TOPBP1 | ENSCAFP00000066175 | ENSCAFP00000009662 | HUS1 checkpoint clamp component. | DNA topoisomerase II binding protein 1. | 0.921 |